MolNFT v1 · #181369 · protein

Structure of full beta-hairpin lir from FNIP2 bound to gabarap

7LSW · Folliculin-interacting protein 2,GAMMA-aminobutyric acid…: “Structure of full beta-hairpin lir from FNIP2 bound to gabarap”. X-ray diffraction, 1 ligand (SO4), 16 pockets (best druggability 0.73). MolNFT v1 #181369 on GenesisL1: 3D…

PDB: 7LSW
Type: protein
Length: 856 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Folliculin-interacting protein 2,GAMMA-aminobutyric acid receptor-associated protein
UniProt: Q9P278, O95166
Ligands: SO4
Pockets: 16 · best druggability 0.73

Structure

x-ray diffraction · 4 distinct chains · 27% helix, 28% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Folliculin-interacting protein 2,GAMMA-aminobutyric acid receptor-associated protein	protein	144	27% helix, 26% strand	Q9P278, O95166
C, D	Folliculin-interacting protein 2,GAMMA-aminobutyric acid receptor-associated protein	protein	145	27% helix, 29% strand	Q9P278, O95166
E	Folliculin-interacting protein 2,GAMMA-aminobutyric acid receptor-associated protein	protein	140	27% helix, 27% strand	Q9P278, O95166
F	Folliculin-interacting protein 2,GAMMA-aminobutyric acid receptor-associated protein	protein	138	28% helix, 28% strand	Q9P278, O95166

Ligands and binding sites

SO4 · Sulfate ion · ion · 7 copies · chains A, B, D, C, F

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

16 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	616	0.73	0.80	76	SO4
2	394	0.71	0.82	58	SO4
3	324	0.69	0.83	46	empty
4	381	0.65	0.79	46	empty
5	194	0.56	0.79	25	empty

Interfaces

9 interfaces between chains.

C–F · 1182 Å² buried · 22 hydrogen bonds · protein-protein
B–D · 1157 Å² buried · 27 hydrogen bonds · protein-protein
B–E · 1145 Å² buried · 16 hydrogen bonds · protein-protein
A–C · 1116 Å² buried · 26 hydrogen bonds · protein-protein
C–E · 684 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

7LSW · Structure of Full Beta-Hairpin LIR from FNIP2 Bound to GABARAP · the same entry in another collection · chain D against D, TM-score 1.00
O95166 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor-associated protein… · a predicted model of the same protein · chain F against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9P278
Every structure of UniProt O95166
Elsewhere: RCSB PDB 7LSW · PDBe 7LSW · UniProt Q9P278 · UniProt O95166

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