MolNFT v1 · #181341 · protein + DNA
Structure of HIV-1 reverse transcriptase in complex with DNA, L-dctp, and CA(2+) ion
7LRX: “Structure of HIV-1 reverse transcriptase in complex with DNA, L-dctp, and CA(2+) ion”. X-ray diffraction, 6 ligands (1S0, GLC, FRU). MolNFT v1 #181341 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7LRX
- Type
- protein + DNA
- Length
- 2,001 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P03366
- Ligands
- 1S0, GLC, FRU, CA, SO4, NH4
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | — | protein | 553 | — | P03366 |
| B | — | protein | 415 | — | P03366 |
| D | — | protein | 410 | — | P03366 |
| F, E | — | dna | 35 | — | — |
Ligands and binding sites
- 1S0 · 4-amino-1-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-L-erythro-pentofuranosyl}pyrimidin-2(1H)-one · ligand · 2 copies · chains A, E, C, F
- GLC · alpha-D-glucopyranose · sugar · 2 copies · chains B, D
- FRU · beta-D-fructofuranose · sugar · 2 copies · chains B, D
- CA · Calcium ion · metal · 2 copies · chains A, C
- SO4 · Sulfate ion · ion · 2 copies · chains A, C
- NH4 · Ammonium ion · ion · 2 copies · chains A, C
- GOL · Glycerol · additive · 2 copies · chains B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7LRX · Structure of HIV-1 Reverse Transcriptase in complex with DNA, L-dCTP, and CA(2+) ion · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P03366
- Elsewhere: RCSB PDB 7LRX · PDBe 7LRX · UniProt P03366
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