MolNFT v1 · #180990 · protein

Structure of human prestin in the presence of sodium sulfate

7LH3: “Structure of human prestin in the presence of sodium sulfate”. Electron microscopy, 20 pockets (best druggability 0.85). MolNFT v1 #180990 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LH3
Type: protein
Length: 1,360 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Prestin
UniProt: P58743
Pockets: 20 · best druggability 0.85

Structure

electron microscopy · 1 distinct chain · 62% helix, 6% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Prestin	protein	680	62% helix, 6% strand	P58743

Pockets

20 pockets found on a 1 Å grid, 15 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	863	0.85	0.87	80	empty
2	90	0.75	0.96	20	empty
3	86	0.74	0.96	20	empty
4	304	0.73	0.86	41	empty
5	292	0.73	0.86	43	empty

Interfaces

1 interface between chains.

A–B · 3963 Å² buried · 41 hydrogen bonds · protein-protein

Compared structures

7LH3 · Structure of human prestin in the presence of sodium sulfate · the same entry in another collection · chain A against A, TM-score 1.00
P58743 · AlphaFold monomer V2.0 prediction for prestin (P58743) · a predicted model of the same protein · chain A against A, TM-score 0.93

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P58743
Elsewhere: RCSB PDB 7LH3 · PDBe 7LH3 · UniProt P58743

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