MolNFT v1 · #180925 · protein
Structure of lysosomal membrane protein
7LF6 · ENDOSOMAL/LYSOSOMAL potassium channel TMEM175: “Structure of lysosomal membrane protein”. Electron microscopy, 16 pockets (best druggability 0.80). MolNFT v1 #180925 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7LF6
- Type
- protein
- Length
- 814 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ENDOSOMAL/LYSOSOMAL potassium channel TMEM175
- UniProt
- Q9BSA9
- Pockets
- 16 · best druggability 0.80
Structure
electron microscopy · 1 distinct chain · 74% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | ENDOSOMAL/LYSOSOMAL potassium channel TMEM175 | protein | 407 | 74% helix, 0% strand | Q9BSA9 |
Pockets
16 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 590 | 0.80 | 0.86 | 59 | empty |
| 2 | 616 | 0.79 | 0.84 | 60 | empty |
| 3 | 82 | 0.71 | 0.95 | 23 | empty |
| 4 | 196 | 0.70 | 0.88 | 31 | empty |
| 5 | 118 | 0.53 | 0.82 | 29 | empty |
Interfaces
1 interface between chains.
- A–B · 3146 Ų buried · 13 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9BSA9
- Elsewhere: RCSB PDB 7LF6 · PDBe 7LF6 · UniProt Q9BSA9
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