MolNFT v1 · #180909 · protein

Structure of importin A2 bound to P50 nls

7LEQ · Importin subunit alpha-1: “Structure of importin A2 bound to P50 nls”. X-ray diffraction, 1 pocket (best druggability 0.43). MolNFT v1 #180909 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LEQ
Type: protein
Length: 430 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Importin subunit alpha-1; Nuclear factor nf-kappa-B P105 subunit
UniProt: P52293, P19838
Pockets: 1 · best druggability 0.43

Structure

x-ray diffraction · 2 distinct chains · 73% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
E	Importin subunit alpha-1	protein	423	74% helix, 0% strand	P52293
B	Nuclear factor nf-kappa-B P105 subunit	protein	7	0% helix, 0% strand	P19838

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	69	0.43	0.81	13	empty

Interfaces

1 interface between chains.

E–B · 718 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

7LEQ · Structure of importin a2 bound to p50 NLS · the same entry in another collection · chain E against E, TM-score 1.00
P19838 · AlphaFold monomer V2.0 prediction for nuclear factor nf-kappa-B P105 subunit (P19838) · a predicted model of the same protein · chain B against A, TM-score 0.59

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P52293
Every structure of UniProt P19838
Elsewhere: RCSB PDB 7LEQ · PDBe 7LEQ · UniProt P52293 · UniProt P19838

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