MolNFT v1 · #180908 · protein
The composite lbd-tmd structure combined from all hippocampal ampar subtypes at 3.25 ångström resolution
7LEP: “The composite lbd-tmd structure combined from all hippocampal ampar subtypes at 3.25 ångström resolution”. Electron microscopy, 6 ligands (POV, ZK1, XVD). MolNFT v1 #180908 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7LEP
- Type
- protein
- Length
- 2,222 residues
- Chains
- 8
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- C9K0Z0, O35089, Q8VHW2
- Ligands
- POV, ZK1, XVD, D12, C14, D10
Structure
electron microscopy · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 403 | — | — |
| B, D | — | protein | 403 | — | C9K0Z0 |
| C | — | protein | 403 | — | — |
| E, F | — | protein | 141 | — | O35089 |
| G, H | — | protein | 164 | — | Q8VHW2 |
Ligands and binding sites
- POV · (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate · ligand · 30 copies · chains A, B, G, F, C, D, H, E
- ZK1 · {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2H)-yl]methyl}phosphonic acid · ligand · 4 copies · chains A, B, C, D
- XVD · 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1H-benzimidazol-2-ol · ligand · 2 copies · chains A, G, C, H
- D12 · Dodecane · ligand · 2 copies · chains G, H
- C14 · Tetradecane · ligand · chains A, B
- D10 · Decane · ligand · chains C
- OCT · N-octane · additive · 2 copies · chains A, G, C, H
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7LEP · The composite LBD-TMD structure combined from all hippocampal AMPAR subtypes at 3.25… · the same entry in another collection · chain H against H, TM-score 1.00
- Q8VHW2 · AlphaFold monomer V2.0 prediction for voltage-dependent calcium channel gamma-8 subunit… · a predicted model of the same protein · chain H against A, TM-score 0.97
- O35089 · AlphaFold monomer V2.0 prediction for protein cornichon homolog 2 (O35089) · a predicted model of the same protein · chain F against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt C9K0Z0
- Every structure of UniProt O35089
- Every structure of UniProt Q8VHW2
- Elsewhere: RCSB PDB 7LEP · PDBe 7LEP · UniProt C9K0Z0 · UniProt O35089 · UniProt Q8VHW2
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