MolNFT v1 · #180761 · protein

Crystal structure of myeloperoxidase subform C (mpo) complex with compound-4

7LAE: “Crystal structure of myeloperoxidase subform C (mpo) complex with compound-4”. X-ray diffraction, 8 ligands (HEM, XRV, NAG). MolNFT v1 #180761 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7LAE
Type: protein
Length: 1,135 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P05164
Ligands: HEM, XRV, NAG, MAN, FUC, BMA, CA, CL

Structure

x-ray diffraction · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D	—	protein	103	—	P05164
B	—	protein	464	—	P05164
E	—	protein	465	—	P05164

Ligands and binding sites

HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B, D, E
XRV · 7-{[1-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl}-1H-[1,2, 3]triazolo[4,5-b]pyridin-5-amine · ligand · 2 copies · chains A, B, D, E
NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 10 copies · chains B, E, D, A
MAN · alpha-D-mannopyranose · sugar · 4 copies · chains B, A, E, D
FUC · alpha-L-fucopyranose · sugar · 2 copies · chains B, E
BMA · beta-D-mannopyranose · sugar · 2 copies · chains B, E
CA · Calcium ion · metal · 2 copies · chains A, B, D, E
CL · Chloride ion · ion · 2 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7LAE · CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH Compound-4 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05164
Elsewhere: RCSB PDB 7LAE · PDBe 7LAE · UniProt P05164

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