UniProt P05164
Isoform H14 of Myeloperoxidase (P05164)
Isoform H14 of Myeloperoxidase (UniProt P05164), EC 1.11.2.2: 54 experimental structures and 1 predicted model on GenesisL1, 25 ligands bound, 42 pockets. Binding sites, druggability and experiment against prediction (TM-score)…
- UniProt
- P05164
- Protein
- Isoform H14 of Myeloperoxidase
- EC
- 1.11.2.2
- Experimental structures
- 54
- Predicted models
- 1
- Ligands
- 25
- Pockets
- 42 · 4 records with a druggable one
Structures
55 records of P05164 in the MolNFT archive: 54 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1CXP | Cryogenic crystal structure of human myeloperoxidase isoform C | x-ray diffraction | A, C, B, D | — | — |
| 1CXP | Cryogenic crystal structure of human myeloperoxidase isoform C | x-ray diffraction | A, C, B, D | — | — |
| 1D2V | Crystal structure of bromide-bound human myeloperoxidase isoform C at pH 5.5 | x-ray diffraction | A, C, B, D | — | — |
| 1D2V | Crystal structure of bromide-bound human myeloperoxidase isoform C at pH 5.5 | x-ray diffraction | A, C, B, D | — | — |
| 1D5L | Crystal structure of cyanide-bound human myeloperoxidase isoform C at pH 5.5 | x-ray diffraction | A, C, B, D | — | — |
| 1D5L | Crystal structure of cyanide-bound human myeloperoxidase isoform C at pH 5.5 | x-ray diffraction | A, C, B, D | — | — |
| 1D7W | Crystal structure of human myeloperoxidase isoform C complexed with cyanide and bromide at pH 4.0 | x-ray diffraction | A, C, B, D | — | — |
| 1D7W | Crystal structure of human myeloperoxidase isoform C complexed with cyanide and bromide at pH 4.0 | x-ray diffraction | A, C, B, D | — | — |
| 1DNU | Structural analyses of human myeloperoxidase-thiocyanate complex | x-ray diffraction | A, C, B, D | — | — |
| 1DNU | Structural analyses of human myeloperoxidase-thiocyanate complex | x-ray diffraction | A, C, B, D | — | — |
| 1DNW | Human myeloperoxidase-cyanide-thiocyanate complex | x-ray diffraction | A, C, B, D | — | — |
| 1DNW | Human myeloperoxidase-cyanide-thiocyanate complex | x-ray diffraction | A, C, B, D | — | — |
| 1MHL | Crystal structure of human myeloperoxidase isoform C crystallized in space group P2(1) at pH 5.5… | x-ray diffraction | A, C, B, D | — | — |
| 1MHL | Crystal structure of human myeloperoxidase isoform C crystallized in space group P2(1) at pH 5.5… | x-ray diffraction | A, C, B, D | — | — |
| 1MYP | X-ray crystal structure of canine myeloperoxidase at 3 ångströms resolution | x-ray diffraction | A, C, B, D | — | — |
| 1MYP | X-ray crystal structure of canine myeloperoxidase at 3 ångströms resolution | x-ray diffraction | A, C, B, D | — | — |
| 3F9P | Crystal structure of myeloperoxidase from human leukocytes | x-ray diffraction | A, C, B, D | — | — |
| 3F9P | Crystal structure of myeloperoxidase from human leukocytes | x-ray diffraction | A, C, B, D | — | — |
| 3ZS0 | Human Myeloperoxidase inactivated by TX2 | x-ray diffraction | A, B, C, D | — | — |
| 3ZS0 | Human myeloperoxidase inactivated by TX2 | x-ray diffraction | A, B, C, D | — | — |
| 3ZS1 | Human Myeloperoxidase inactivated by TX5 | x-ray diffraction | A, B, C, D | — | — |
| 3ZS1 | Human myeloperoxidase inactivated by TX5 | x-ray diffraction | A, B, C, D | — | — |
| 4C1M | Myeloperoxidase in complex with the revesible inhibitor HX1 | x-ray diffraction | A, B, C, D | — | — |
| 4C1M | Myeloperoxidase in complex with the revesible inhibitor HX1 | x-ray diffraction | A, B, C, D | — | — |
| 4DL1 | Crystal Structure of human Myeloperoxidase with covalent thioxanthine analog | x-ray diffraction | A, C, B, D, E, G, F, H, I, K, J, L, M, O, N, P | — | — |
| 4DL1 | Crystal structure of human myeloperoxidase with covalent thioxanthine analog | x-ray diffraction | A, C, B, D, E, G, F, H, I, K, J, L, M, O, N, P | — | — |
| 4EJX | Structure of ceruloplasmin-myeloperoxidase complex | x-ray diffraction | B, D | — | — |
| 4EJX | Structure of ceruloplasmin-myeloperoxidase complex | x-ray diffraction | B, D | — | — |
| 5FIW | Crystal structure of human myeloperoxidase at 1.7 ångströms resolution | x-ray diffraction | A, B, C, D | NAG, BMA, MAN, FUC, CL, HEM | — |
| 5FIW | Crystal structure of human myeloperoxidase at 1.7 ångströms resolution | x-ray diffraction | A, B, C, D | — | — |
| 5MFA | Crystal structure of human promyeloperoxidase (proMPO) | x-ray diffraction | A | NAG, BMA, MAN, HEM, CA, CL | 4 (best 0.81) |
| 5MFA | Crystal structure of human promyeloperoxidase (prompo) | x-ray diffraction | A | NAG, BMA, MAN, HEM, CA, CL | — |
| 5QJ2 | Crystal structure of myeloperoxidase subform C (mpo) omplex with compound-20 aka… | x-ray diffraction | A, B, D, E, F, G, H, I | NAG, FUC, HEM, BMA, MAN, JXS | — |
| 5QJ3 | Crystal structure of myeloperoxidase subform C (mpo) complex with compound-24 aka… | x-ray diffraction | A, B, D, E | NAG, BMA, MAN, FUC, CL, HEM | — |
| 5UZU | Immune evasion by a staphylococcal peroxidase inhibitor that blocks myeloperoxidase | x-ray diffraction | A | NAG, CA, CL | — |
| 5WDJ | Crystal structure of myeloperoxidase subform C (mpo) complex with compound-6 aka… | x-ray diffraction | A, B, D, E | NAG, BMA, MAN, AEY, CL, HEM | — |
| 5WDJ | Crystal structure of myeloperoxidase subform C (mpo) complex with compound-6 aka… | x-ray diffraction | A, B, D, E | NAG, BMA, MAN, AEY, CL, HEM | — |
| 6AZP | A structurally dynamic N-terminal region drives function of the staphylococcal peroxidase inhibitor… | x-ray diffraction | A | NAG, CA | — |
| 6BMT | Crystal Structure of a Recombinant form of Human Myeloperoxidase Bound to an Inhibitor from… | x-ray diffraction | A | CA, HEM, CL, NAG | 9 (best 0.85) |
| 6BMT | Crystal structure of a recombinant form of human myeloperoxidase bound to an inhibitor from… | x-ray diffraction | A | CA, HEM, CL, NAG | — |
| 6WXZ | Crystal structure of myeloperoxidase subform C (mpo) complex with compound-29 A.K.A… | x-ray diffraction | A, B, D, E | NAG, FUC, BMA, MAN, CL, CA | — |
| 6WY0 | Crystal structure of myeloperoxidase subform C (mpo) complex with compound-40 A.K.A… | x-ray diffraction | A, B, D, E, F, G, H, I | NAG, BMA, MAN, FUC, HEC, CA | — |
| 6WY5 | Crystal structure of myeloperoxidase subform C (mpo) complex with compound-37 A.K.A… | x-ray diffraction | A, B, D, E | NAG, BMA, MAN, FUC, HEC, CL | — |
| 6WY7 | Crystal structure of myeloperoxidase subform C (mpo) complex with compound-41 A.K.A… | x-ray diffraction | A, B, D, E | NAG, BMA, MAN, FUC, CL, HEC | — |
| 6WYD | Crystal structure of myeloperoxidase subform C (mpo) complex with compound-12 (aka… | x-ray diffraction | A, B, D, E, F, G, H, I | CL, NAG, FUC, HEC, BMA, MAN | — |
| 7LAE | Crystal structure of myeloperoxidase subform C (mpo) complex with compound-4 | x-ray diffraction | A, B, D, E | NAG, CL, HEM, FUC, BMA, MAN | — |
| 7LAG | Crystal structure of myeloperoxidase subform C (mpo) complex with compound-14 aka… | x-ray diffraction | A, B, D, E, F, G, H, I | NAG, BMA, MAN, FUC, CL, HEM | — |
| 7LAL | Crystal structure of myeloperoxidase subform C (mpo) complex with compound-18 aka… | x-ray diffraction | A, B, D, E | NAG, BMA, FUC, CL, HEM, MAN | — |
| 7LAN | CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH COMPOUND-30 AKA… | x-ray diffraction | A, B, D, E, F, G, H, I | NAG, BMA, MAN, FUC, CL, HEM | 20 (best 0.81) |
| 7LAN | Crystal structure of myeloperoxidase subform C (mpo) complex with compound-30 aka… | x-ray diffraction | A, B, D, E, F, G, H, I | NAG, BMA, MAN, FUC, CL, HEM | — |
| 7NI1 | Crystal structure of native human myeloperoxidase in complex with cpd 9 | x-ray diffraction | A, B, C, D | NAG, BMA, MAN, FUC, CL, HEM | — |
| 7NI3 | Crystal structure of native human myeloperoxidase in complex with cpd 3 | x-ray diffraction | A, B, C, D | NAG, BMA, FUC, HEM, CL, UE8 | — |
| 7NI3 | Crystal structure of native human myeloperoxidase in complex with cpd 3 | x-ray diffraction | A, B, C, D | NAG, BMA, FUC, HEM, CL, UE8 | — |
| 7OIH | Glycosylation in the crystal structure of neutrophil myeloperoxidase | x-ray diffraction | A, B, C, D, E, F, G, H | NAG, BMA, MAN, FUC, CL, CA | — |
| P05164 | AlphaFold monomer V2.0 prediction for myeloperoxidase (P05164) | predicted | A | — | 9 (best 0.86) |
Ligands
- CA · Calcium ion · in 25 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 25 records
- CL · Chloride ion · in 24 records
- BMA · beta-D-mannopyranose · in 21 records
- FUC · alpha-L-fucopyranose · in 19 records
- MAN · alpha-D-mannopyranose · in 19 records
- HEM · Protoporphyrin IX containing Fe · in 18 records
- HEC · Heme C · in 5 records
- AEY · 7-(benzyloxy)-1H-[1,2,3]triazolo[4,5-d]pyrimidin-5-amine · in 2 records
- UE8 · 2-sulfanylidene-3-[(2R)-tetrahydro-2-furanylmethyl]-1, 2,3,7-tetrahydro-6H-purin-6-one · in 2 records
- XS1 · 7-[(3R,4S,6S,10R)-4-benzyl-2-oxa-7,13,14-triazatetracyclo[14.3.1.1~3,6~.1~11,14~]docosa-1(20), 11(21),12,16,18-pentaen-10-yl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine · in 2 records
- 7GD · 7-benzyl-1H-[1,2,3]triazolo[4,5-b]pyridin-5-amine · in 1 record
- 8PR · Paroxetine · in 1 record
- JXP · 7-[(4-chloro-3'-fluoro[1,1'-biphenyl]-3-yl)methoxy]-1H-[1,2,3]triazolo[4,5-b]pyridin-5-amine · in 1 record
- JXS · 7-{[3-(1-methyl-1H-pyrazol-3-yl)phenyl]methoxy}-1H-[1, 2,3]triazolo[4,5-b]pyridin-5-amine · in 1 record
- PO4 · Phosphate ion · in 1 record
- SCN · Thiocyanate ion · in 1 record
- UEB · (S)-1-(2-(amino(phenyl)methyl)benzyl)-2-thioxo-1,2,3,5-tetrahydro-4H-pyrrolo[3,2-d]pyrimidin-4-one · in 1 record
- UEY · 7-[(1R)-1,2-diphenylethyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine · in 1 record
- UF7 · 7-[(1R)-1-phenyl-3-{[(1S,3S)-3-phenyl-2,3-dihydro-1H-inden-1-yl]amino}propyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine · in 1 record
- UFA · 7-{(1R)-1-phenyl-3-[(trans-4-phenylcyclohexyl) amino]propyl}-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine · in 1 record
- UFD · 7-{(1R)-1-phenyl-3-[(4-phenylbicyclo[2.2.2]octan-1-yl) amino]propyl}-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine · in 1 record
- XRV · 7-{[1-(4-fluorophenyl)-1H-pyrazol-4-yl]methyl}-1H-[1,2, 3]triazolo[4,5-b]pyridin-5-amine · in 1 record
- XSD · 7-({1-[(3-phenoxyphenyl)methyl]-1H-pyrazol-4-yl}methyl)-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine · in 1 record
- XSG · 7-[(1R)-3-{[(1R)-2,3-dihydro-1H-inden-1-yl]amino}-1-phenylpropyl]-3H-[1,2,3]triazolo[4,5-b]pyridin-5-amine · in 1 record
Experiment against prediction
- 6BMT chain A against the predicted model P05164: TM-score 0.99, RMSD 1.19 Å
- 6BMT chain A against the predicted model P05164: TM-score 0.99, RMSD 1.19 Å
- 7LAN chain G against the predicted model P05164: TM-score 0.99, RMSD 1.11 Å
- 7LAN chain E against the predicted model P05164: TM-score 0.99, RMSD 1.12 Å
- 6WY0 chain E against the predicted model P05164: TM-score 0.99, RMSD 1.13 Å
- 7LAN chain B against the predicted model P05164: TM-score 0.99, RMSD 1.12 Å
- 7LAN chain I against the predicted model P05164: TM-score 0.99, RMSD 1.12 Å
- 6WY7 chain E against the predicted model P05164: TM-score 0.99, RMSD 1.12 Å
- 6WY7 chain B against the predicted model P05164: TM-score 0.99, RMSD 1.13 Å
- 6WY0 chain B against the predicted model P05164: TM-score 0.99, RMSD 1.13 Å
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.