MolNFT v1 · #180647 · protein
Unliganded elic in styrene-maleic-acid nanodiscs at 2.5-ångström resolution
7L6Q · Gamma-aminobutyric-acid receptor subunit beta-1: “Unliganded elic in styrene-maleic-acid nanodiscs at 2.5-ångström resolution”. Electron microscopy, 2 ligands (PGW, CDL), 20 pockets (best druggability 0.81). MolNFT v1 #180647 on…
- PDB
- 7L6Q
- Type
- protein
- Length
- 1,555 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-aminobutyric-acid receptor subunit beta-1
- UniProt
- E0SJQ4
- Ligands
- PGW, CDL
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 1 distinct chain · 36% helix, 32% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E | Gamma-aminobutyric-acid receptor subunit beta-1 | protein | 311 | 36% helix, 32% strand | E0SJQ4 |
Ligands and binding sites
- PGW · (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy) phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate · ligand · 5 copies · chains A, B, E, C, D
- CDL · Cardiolipin · ligand · 5 copies · chains A, E, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 155 | 0.81 | 0.97 | 20 | empty |
| 2 | 787 | 0.79 | 0.83 | 79 | empty |
| 3 | 737 | 0.79 | 0.83 | 71 | empty |
| 4 | 712 | 0.78 | 0.83 | 68 | empty |
| 5 | 853 | 0.78 | 0.81 | 81 | empty |
Interfaces
10 interfaces between chains.
- A–E · 2532 Ų buried · 21 hydrogen bonds · protein-protein
- C–D · 2525 Ų buried · 22 hydrogen bonds · protein-protein
- B–C · 2523 Ų buried · 21 hydrogen bonds · protein-protein
- D–E · 2522 Ų buried · 22 hydrogen bonds · protein-protein
- A–B · 2519 Ų buried · 22 hydrogen bonds · protein-protein
Compared structures
- 7L6Q · Unliganded ELIC in styrene-maleic-acid nanodiscs at 2.5-Angstrom resolution · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt E0SJQ4
- Elsewhere: RCSB PDB 7L6Q · PDBe 7L6Q · UniProt E0SJQ4
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.