MolNFT v1 · #180399 · protein
Structure of the S. cerevisiae phosphatidylcholine flippase DNF2-LEM3 complex in the E1-ATP state
7KY8: “Structure of the S. cerevisiae phosphatidylcholine flippase DNF2-LEM3 complex in the E1-ATP state”. Electron microscopy, 5 ligands (CLR, ACP, NAG). MolNFT v1 #180399 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7KY8
- Type
- protein
- Length
- 1,274 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q12675, P42838
- Ligands
- CLR, ACP, NAG, MAN, MG
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 910 | — | Q12675 |
| B | — | protein | 364 | — | P42838 |
Ligands and binding sites
- CLR · Cholesterol · ligand · 5 copies · chains A, B
- ACP · Phosphomethylphosphonic acid adenylate ester · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 9 copies · chains B, A
- MAN · alpha-D-mannopyranose · sugar · 3 copies
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7KY8 · Structure of the S. cerevisiae phosphatidylcholine flippase Dnf2-Lem3 complex in the… · the same entry in another collection · chain A against A, TM-score 1.00
- P42838 · AlphaFold monomer V2.0 prediction for alkylphosphocholine resistance protein LEM3 (P42838) · a predicted model of the same protein · chain B against A, TM-score 0.97
- Q12675 · AlphaFold monomer V2.0 prediction for phospholipid-transporting ATPase DNF2 (Q12675) · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12675
- Every structure of UniProt P42838
- Elsewhere: RCSB PDB 7KY8 · PDBe 7KY8 · UniProt Q12675 · UniProt P42838
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