UniProt Q12675
Phospholipid-transporting ATPase DNF2 (Q12675)
Phospholipid-transporting ATPase DNF2 (UniProt Q12675), EC 7.6.2.1: 10 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 86 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q12675
- Protein
- Phospholipid-transporting ATPase DNF2
- EC
- 7.6.2.1
- Experimental structures
- 10
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 86 · 5 records with a druggable one
Structures
11 records of Q12675 in the MolNFT archive: 10 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7KY5 | Structure of the S. cerevisiae phosphatidylcholine flippase Dnf2-Lem3 complex in the E2P transition… | electron microscopy | A | CLR, ALF, MG | 19 (best 0.80) |
| 7KY5 | Structure of the S. cerevisiae phosphatidylcholine flippase DNF2-LEM3 complex in the E2P transition… | electron microscopy | A | CLR, ALF, MG | — |
| 7KY7 | Structure of the S. cerevisiae phosphatidylcholine flippase Dnf2-Lem3 complex in the apo E1 state | electron microscopy | A | NAG, MG, CLR | 10 (best 0.81) |
| 7KY7 | Structure of the S. cerevisiae phosphatidylcholine flippase DNF2-LEM3 complex in the apo E1 state | electron microscopy | A | NAG, MG, CLR | — |
| 7KY8 | Structure of the S. cerevisiae phosphatidylcholine flippase Dnf2-Lem3 complex in the E1-ATP state | electron microscopy | A | NAG, CLR, MG, ACP | 19 (best 0.77) |
| 7KY8 | Structure of the S. cerevisiae phosphatidylcholine flippase DNF2-LEM3 complex in the E1-ATP state | electron microscopy | A | NAG, CLR, MG, ACP | — |
| 7KY9 | Structure of the S. cerevisiae phosphatidylcholine flippase Dnf2-Lem3 complex in the E1-ADP state | electron microscopy | A | NAG, ADP, ALF, MG | 19 (best 0.80) |
| 7KY9 | Structure of the S. cerevisiae phosphatidylcholine flippase DNF2-LEM3 complex in the E1-ADP state | electron microscopy | A | ADP, ALF, MG | — |
| 7KYA | Structure of the S. cerevisiae phosphatidylcholine flippase Dnf2-Lem3 complex in the E2P state | electron microscopy | A | NAG, CLR, MG, BEF | 19 (best 0.77) |
| 7KYA | Structure of the S. cerevisiae phosphatidylcholine flippase DNF2-LEM3 complex in the E2P state | electron microscopy | A | NAG, CLR, MG, BEF | — |
| Q12675 | AlphaFold monomer V2.0 prediction for phospholipid-transporting ATPase DNF2 (Q12675) | predicted | A | — | — |
Ligands
- MG · Magnesium ion · in 10 records
- CLR · Cholesterol · in 8 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 7 records
- ALF · Tetrafluoroaluminate ion · in 4 records
- ACP · Phosphomethylphosphonic acid adenylate ester · in 2 records
- ADP · Adenosine-5'-diphosphate · in 2 records
- BEF · Beryllium trifluoride ion · in 2 records
Experiment against prediction
- 7KYA chain A against the predicted model Q12675: TM-score 0.99, RMSD 0.99 Å
- 7KYA chain A against the predicted model Q12675: TM-score 0.99, RMSD 0.99 Å
- 7KY5 chain A against the predicted model Q12675: TM-score 0.97, RMSD 2.31 Å
- 7KY5 chain A against the predicted model Q12675: TM-score 0.97, RMSD 2.31 Å
- 7KY7 chain A against the predicted model Q12675: TM-score 0.86, RMSD 4.49 Å
- 7KY7 chain A against the predicted model Q12675: TM-score 0.86, RMSD 4.49 Å
- 7KY8 chain A against the predicted model Q12675: TM-score 0.80, RMSD 5.25 Å
- 7KY8 chain A against the predicted model Q12675: TM-score 0.80, RMSD 5.25 Å
- 7KY9 chain A against the predicted model Q12675: TM-score 0.79, RMSD 5.26 Å
- 7KY9 chain A against the predicted model Q12675: TM-score 0.79, RMSD 5.26 Å
Elsewhere
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