MolNFT v1 · #180181 · protein
The gr-maturation complex: glucocorticoid receptor in complex with HSP90 and co-chaperone P23
7KRJ: “The gr-maturation complex: glucocorticoid receptor in complex with HSP90 and co-chaperone P23”. Electron microscopy, 3 ligands (ATP, DEX, MG). MolNFT v1 #180181 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7KRJ
- Type
- protein
- Length
- 1,642 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P07900, Q15185, P04150
- Ligands
- ATP, DEX, MG
Structure
electron microscopy · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | — | protein | 627 | — | P07900 |
| C | — | protein | 133 | — | Q15185 |
| D | — | protein | 255 | — | P04150 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A, B
- DEX · Dexamethasone · ligand · chains D
- MG · Magnesium ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7KRJ · The GR-Maturation Complex: Glucocorticoid Receptor in complex with Hsp90 and co-chaperone… · the same entry in another collection · chain D against D, TM-score 1.00
- P07900 · AlphaFold monomer V2.0 prediction for heat shock protein HSP 90-alpha (P07900) · a predicted model of the same protein · chain B against A, TM-score 0.99
- P04150 · AlphaFold monomer V2.0 prediction for glucocorticoid receptor (P04150) · a predicted model of the same protein · chain D against A, TM-score 0.97
- Q15185 · AlphaFold monomer V2.0 prediction for prostaglandin E synthase 3 (Q15185) · a predicted model of the same protein · chain C against A, TM-score 0.84
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07900
- Every structure of UniProt Q15185
- Every structure of UniProt P04150
- Elsewhere: RCSB PDB 7KRJ · PDBe 7KRJ · UniProt P07900 · UniProt Q15185 · UniProt P04150
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