MolNFT v1 · #180054 · protein
Cryoem structure of the apo-cgrp receptor in a detergent micelle
7KNT · Receptor activity-modifying protein 1: “Cryoem structure of the apo-cgrp receptor in a detergent micelle”. Electron microscopy, 5 pockets (best druggability 0.70). MolNFT v1 #180054 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7KNT
- Type
- protein
- Length
- 455 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Receptor activity-modifying protein 1; Calcitonin gene-related peptide type 1 receptor
- UniProt
- O60894, Q16602
- Pockets
- 5 · best druggability 0.70
Structure
electron microscopy · 2 distinct chains · 66% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| E | Receptor activity-modifying protein 1 | protein | 114 | 68% helix, 0% strand | O60894 |
| R | Calcitonin gene-related peptide type 1 receptor | protein | 341 | 65% helix, 4% strand | Q16602 |
Pockets
5 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 801 | 0.70 | 0.76 | 61 | empty |
| 2 | 116 | 0.59 | 0.85 | 22 | empty |
| 3 | 367 | 0.57 | 0.75 | 32 | empty |
| 4 | 157 | 0.56 | 0.81 | 20 | empty |
| 5 | 248 | 0.52 | 0.75 | 34 | empty |
Interfaces
1 interface between chains.
- E–R · 2110 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 7KNT · CryoEM structure of the apo-CGRP receptor in a detergent micelle · the same entry in another collection · chain E against E, TM-score 1.00
- O60894 · AlphaFold monomer V2.0 prediction for receptor activity-modifying protein 1 (O60894) · a predicted model of the same protein · chain E against A, TM-score 0.92
- Q16602 · AlphaFold monomer V2.0 prediction for calcitonin gene-related peptide type 1 receptor… · a predicted model of the same protein · chain R against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O60894
- Every structure of UniProt Q16602
- Elsewhere: RCSB PDB 7KNT · PDBe 7KNT · UniProt O60894 · UniProt Q16602
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