Solution structure of the PHD1 domain of histone demethylase KDM5A in complex with a histone H3(1-10) peptide

Structure

solution nmr · 2 distinct chains · 20% helix, 6% strand (DSSP).

Ligands and binding sites

• ZN · Zinc ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Interfaces

1 interface between chains.

• A–B · 488 Ų buried · 5 hydrogen bonds · protein-protein

Compared structures

• 7KLR · Solution structure of the PHD1 domain of histone demethylase KDM5A in complex with a… · the same entry in another collection · chain B against B, TM-score 1.00
• P29375 · AlphaFold monomer V2.0 prediction for lysine-specific demethylase 5A (P29375) · a predicted model of the same protein · chain A against A, TM-score 0.62
• P68431 · AlphaFold monomer V2.0 prediction for histone H3.1 (P68431) · a predicted model of the same protein · chain B against A, TM-score 0.51

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P29375
• Every structure of UniProt P68431
• Elsewhere: RCSB PDB 7KLR · PDBe 7KLR · UniProt P29375 · UniProt P68431