MolNFT v1 · #17986 · protein

Yersinia protein-tyrosine phosphatase complexed with pncs (YOP51, pasteurella X,PTPASE,YOP51DELTA162) (catalytic domain, residues 163- 468) mutant with cys 235 replaced by arg (C235R)

1PA9 · Protein-tyrosine phosphatase yoph: “Yersinia protein-tyrosine phosphatase complexed with pncs (YOP51, pasteurella X,PTPASE,YOP51DELTA162)…”. X-ray diffraction, 1 ligand (CSN), 1 pocket (best druggability 0.39). MolNFT v1 #17986 on…

PDB: 1PA9
Type: protein
Length: 279 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein-tyrosine phosphatase yoph
EC: 3.1.3.48
UniProt: P15273
Ligands: CSN
Pockets: 1 · best druggability 0.39

Structure

x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein-tyrosine phosphatase yoph (EC 3.1.3.48)	protein	279	38% helix, 21% strand	P15273

Ligands and binding sites

CSN · N,4-dihydroxy-N-oxo-3-(sulfooxy)benzenaminium · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	100	0.39	0.76	19	empty

Compared structures

1PA9 · Yersinia Protein-Tyrosine Phosphatase complexed with pNCS (Yop51,Pasteurella… · the same entry in another collection · chain A against A, TM-score 1.00
P15273 · AlphaFold monomer V2.0 prediction for tyrosine-protein phosphatase yoph (P15273) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P15273
Elsewhere: RCSB PDB 1PA9 · PDBe 1PA9 · UniProt P15273

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