Ternary complex of VHL/BRD4-BD1/COMPOUND9 (4-(3,5-difluoropyridin-2- yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl) BENZYL)CARBAMOYL)PYRROLIDIN-1-yl)-3,3-dimethyl-1-oxobutan-2-yl) amino)-11-oxoundecyl)-10-methyl-7-((METHYLSULFONYL)METHYL)-11-oxo-3, 4,10,11-tetrahydro-1H-1,4,10-TRIAZADIBENZO[CD,F]AZULENE-6- carboxamide)

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• WEP · N-[11-({7-(3,5-difluoropyridin-2-yl)-2-methyl-10-[(methylsulfonyl)methyl]-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carbonyl}amino) undecanoyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide · ligand · chains C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7KHH · Ternary complex of VHL/BRD4-BD1/Compound9 (4-(3,5-difluoropyridin-2-yl)-N-(11-(((S)-1-((2S… · the same entry in another collection · chain A against A, TM-score 1.00
• Q15370 · AlphaFold monomer V2.0 prediction for elongin-B (Q15370) · a predicted model of the same protein · chain A against A, TM-score 0.98
• O60885 · AlphaFold monomer V2.0 prediction for bromodomain-containing protein 4 (O60885) · a predicted model of the same protein · chain D against A, TM-score 0.98
• Q15369 · AlphaFold monomer V2.0 prediction for elongin-C (Q15369) · a predicted model of the same protein · chain B against A, TM-score 0.96

Analyse

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• Every structure of UniProt Q15370
• Every structure of UniProt Q15369
• Every structure of UniProt P40337
• Every structure of UniProt O60885
• Elsewhere: RCSB PDB 7KHH · PDBe 7KHH · UniProt Q15370 · UniProt Q15369 · UniProt P40337 · UniProt O60885