GL1X · GenesisL1 explorer

Ligand · WEP

WEP · N-[11-({7-(3,5-difluoropyridin-2-yl)-2-methyl-10-[(methylsulfonyl)methyl]-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carbonyl}amino) undecanoyl]-3-methyl-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide

WEP, N-[11-({7-(3,5-difluoropyridin-2-yl)-2-methyl-10-[(methylsulfonyl)methyl]-3-oxo-3,4,6,7-tetrahydro-2H-2,4,7-triazadibenzo[cd,f]azulene-9-carbonyl}amino)…

Component
WEP
Formula
C56 H67 F2 N9 O8 S2
Class
ligand
Structures
2
PDB entries
1

Binding sites

WEP in 2 structures; the first of them:

  • 7KHH · Ternary complex of VHL/BRD4-BD1/Compound9 (4-(3,5-difluoropyridin-2-yl)-N-(11-(((S)-1-((2S… · WEP C301 · binds ASN67, ARG69, TRP88, PHE91, TYR98, ILE109, HIS110, SER111 and 19 more
  • 7KHH · Ternary complex of VHL/BRD4-BD1/COMPOUND9 (4-(3,5-difluoropyridin-2… · WEP C301 · binds ASN67, TRP88, PHE91, TYR98, HIS110, SER111, TYR112, HIS115 and 15 more

Residues it binds most

TRP 2, TYR 2, ASN 2, ASP 2, HIS 2, LEU 2, PHE 2, PRO 2, ILE 2, GLN 2 (residue and the binding sites it lines).

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