MolNFT v1 · #17944 · protein
The calcium-activated C-terminal half of gelsolin
1P8X · Gelsolin precursor, plasma: “The calcium-activated C-terminal half of gelsolin”. X-ray diffraction, 1 ligand (CA), 10 pockets (best druggability 0.60). MolNFT v1 #17944 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1P8X
- Type
- protein
- Length
- 965 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gelsolin precursor, plasma
- UniProt
- P06396
- Ligands
- CA
- Pockets
- 10 · best druggability 0.60
Structure
x-ray diffraction · 3 distinct chains · 24% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Gelsolin precursor, plasma | protein | 316 | 24% helix, 29% strand | P06396 |
| B | Gelsolin precursor, plasma | protein | 325 | 24% helix, 28% strand | P06396 |
| C | Gelsolin precursor, plasma | protein | 324 | 24% helix, 29% strand | P06396 |
Ligands and binding sites
- CA · Calcium ion · metal · 9 copies · chains A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 187 | 0.60 | 0.82 | 37 | empty |
| 2 | 228 | 0.59 | 0.80 | 40 | empty |
| 3 | 236 | 0.59 | 0.80 | 30 | empty |
| 4 | 244 | 0.58 | 0.79 | 31 | empty |
| 5 | 301 | 0.56 | 0.76 | 28 | empty |
Interfaces
3 interfaces between chains.
- A–B · 358 Ų buried · 3 hydrogen bonds · protein-protein
- A–C · 139 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 108 Ų buried · 2 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06396
- Elsewhere: RCSB PDB 1P8X · PDBe 1P8X · UniProt P06396
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