Crystal structure of protac MS33 in complex with the wd repeat- containing protein 5 and PVHL:ELONGINC:ELONGINB

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• VKA · 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl) phenyl]methyl}-L-prolinamide · ligand · chains B, L
• NA · Sodium ion · metal · chains L
• SCN · Thiocyanate ion · ion · 4 copies · chains B, J
• EDO · 1,2-ethanediol · additive · 5 copies · chains B, K, L
• GOL · Glycerol · additive · chains K

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7JTO · Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and… · the same entry in another collection · chain B against B, TM-score 1.00
• Q15370 · AlphaFold monomer V2.0 prediction for elongin-B (Q15370) · a predicted model of the same protein · chain J against A, TM-score 0.98
• Q15369 · AlphaFold monomer V2.0 prediction for elongin-C (Q15369) · a predicted model of the same protein · chain K against A, TM-score 0.98

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P61964
• Every structure of UniProt Q15370
• Every structure of UniProt Q15369
• Every structure of UniProt P40337
• Elsewhere: RCSB PDB 7JTO · PDBe 7JTO · UniProt P61964 · UniProt Q15370 · UniProt Q15369 · UniProt P40337