MolNFT v1 · #178786 · protein

The internal aldimine crystal structure of salmonella typhimurium tryptophan synthase mutant beta-S377A in complex with inhibitor 2- ({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL dihydrogen phosphate (F9F) at the alpha-site, cesium ion at the metal coordination site and L-tryptophan at the enzyme beta-site

7JLL: “The internal aldimine crystal structure of salmonella typhimurium tryptophan synthase mutant beta-S377A in…”. X-ray diffraction, 4 ligands (F9F, PLP, CS). MolNFT v1 #178786 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 7JLL
Type: protein
Length: 664 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P00929, P0A2K1
Ligands: F9F, PLP, CS, CL

Structure

x-ray diffraction · 2 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	268	—	P00929
B	—	protein	396	—	P0A2K1

Ligands and binding sites

F9F · 2-({[4-(trifluoromethoxy)phenyl]sulfonyl}amino)ethyl dihydrogen phosphate · ligand · chains A, B
PLP · Pyridoxal-5'-phosphate · ligand · chains B
CS · Cesium ion · metal · 3 copies · chains A, B
CL · Chloride ion · ion · 23 copies · chains A, B
DMS · Dimethyl sulfoxide · additive · 24 copies · chains A, B
EDO · 1,2-ethanediol · additive · 3 copies · chains B
PEG · Di(hydroxyethyl)ether · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00929
Every structure of UniProt P0A2K1
Elsewhere: RCSB PDB 7JLL · PDBe 7JLL · UniProt P00929 · UniProt P0A2K1

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