MolNFT v1 · #178781 · protein + DNA

Human primpol extending from the erroneous primer base a opposite the 8-oxoguanine lesion

7JLG: “Human primpol extending from the erroneous primer base a opposite the 8-oxoguanine lesion”. X-ray diffraction, 2 ligands (DTP, CA). MolNFT v1 #178781 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7JLG
Type: protein + DNA
Length: 568 residues
Chains: 6
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: Q96LW4
Ligands: DTP, CA

Structure

x-ray diffraction · 6 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	268	—	Q96LW4
C	—	dna	14	—	—
D	—	dna	11	—	—
B	—	protein	250	—	Q96LW4
G	—	dna	16	—	—
H	—	dna	9	—	—

Ligands and binding sites

DTP · 2'-deoxyadenosine 5'-triphosphate · ligand · 2 copies · chains A, C, D, B, G, H
CA · Calcium ion · metal · 4 copies · chains A, D, B, H
GOL · Glycerol · additive · 2 copies · chains B, H
PEG · Di(hydroxyethyl)ether · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7JLG · Human PrimPol extending from the erroneous primer base A opposite the 8-oxoguanine lesion · the same entry in another collection · chain H against H, TM-score 1.00
Q96LW4 · AlphaFold monomer V2.0 prediction for DNA-directed PRIMASE/POLYMERASE protein (Q96LW4) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96LW4
Elsewhere: RCSB PDB 7JLG · PDBe 7JLG · UniProt Q96LW4

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