UniProt Q96LW4
DNA-directed primase/polymerase protein (Q96LW4)
DNA-directed primase/polymerase protein (UniProt Q96LW4), EC 2.7.7.-: 11 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 12 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q96LW4
- Protein
- DNA-directed primase/polymerase protein
- EC
- 2.7.7.-
- Experimental structures
- 11
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 12 · 2 records with a druggable one
Structures
12 records of Q96LW4 in the MolNFT archive: 11 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5L2X | Crystal structure of human PrimPol ternary complex | x-ray diffraction | A, B | DTP, CA | 7 (best 0.70) |
| 5L2X | Crystal structure of human primpol ternary complex | x-ray diffraction | A, B | DTP, CA | — |
| 5N85 | Structure of RPA70N in complex with primpol (fragment 514-525) | x-ray diffraction | B | — | — |
| 5N8A | Structure of RPA70N in complex with PrimPol (fragment 480-560) | x-ray diffraction | X | — | — |
| 5N8A | Structure of RPA70N in complex with primpol (fragment 480-560) | x-ray diffraction | X | — | — |
| 7JK1 | Human primpol inserting correct dctp opposite the 8-oxoguanine lesion | x-ray diffraction | A, B | DCP, CA | — |
| 7JKL | Human PrimPol misinserting dATP opposite the 8-oxoguanine lesion (3'-end base of the primer strand… | x-ray diffraction | A, B | DTP, CA | — |
| 7JKL | Human primpol misinserting datp opposite the 8-oxoguanine lesion (3'- end base of the primer strand… | x-ray diffraction | A, B | DTP, CA | — |
| 7JKP | Human primpol misinserting datp opposite the 8-oxoguanine lesion | x-ray diffraction | A, B | DTP, CA | — |
| 7JL8 | Human primpol extending from the correct primer base C opposite the 8- oxoguanine lesion | x-ray diffraction | A, B | DTP, CA | — |
| 7JLG | Human primpol extending from the erroneous primer base a opposite the 8-oxoguanine lesion | x-ray diffraction | A, B | DTP, CA | — |
| Q96LW4 | AlphaFold monomer V2.0 prediction for DNA-directed PRIMASE/POLYMERASE protein (Q96LW4) | predicted | A | — | 5 (best 0.64) |
Ligands
Experiment against prediction
- 7JLG chain B against the predicted model Q96LW4: TM-score 0.99, RMSD 0.62 Å
- 7JL8 chain B against the predicted model Q96LW4: TM-score 0.99, RMSD 0.65 Å
- 7JKL chain B against the predicted model Q96LW4: TM-score 0.99, RMSD 0.74 Å
- 7JKL chain B against the predicted model Q96LW4: TM-score 0.99, RMSD 0.74 Å
- 5L2X chain B against the predicted model Q96LW4: TM-score 0.99, RMSD 0.76 Å
- 5L2X chain B against the predicted model Q96LW4: TM-score 0.99, RMSD 0.76 Å
- 7JK1 chain B against the predicted model Q96LW4: TM-score 0.99, RMSD 0.79 Å
- 7JKP chain B against the predicted model Q96LW4: TM-score 0.99, RMSD 0.76 Å
- 7JKP chain A against the predicted model Q96LW4: TM-score 0.93, RMSD 0.94 Å
- 7JLG chain A against the predicted model Q96LW4: TM-score 0.93, RMSD 0.94 Å
Elsewhere
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