MolNFT v1 · #178766 · protein + RNA

Cryo-EM structure of rig-I:DSRNA in complex with riplet pryspry domain (monomer)

7JL1: “Cryo-EM structure of rig-I:DSRNA in complex with riplet pryspry domain (monomer)”. Electron microscopy, 4 ligands (ADP, ALF, MG). MolNFT v1 #178766 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7JL1
Type: protein + RNA
Length: 855 residues
Chains: 4
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: O95786, Q8IUD6
Ligands: ADP, ALF, MG, ZN

Structure

electron microscopy · 4 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	656	—	O95786
X	—	rna	14	—	—
Y	—	rna	14	—	—
B	—	protein	171	—	Q8IUD6

Ligands and binding sites

ADP · Adenosine-5'-diphosphate · ligand · chains A
ALF · Tetrafluoroaluminate ion · ligand · chains A
MG · Magnesium ion · metal · chains A
ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

7JL1 · Cryo-EM structure of RIG-I:dsRNA in complex with RIPLET PrySpry domain (monomer) · the same entry in another collection · chain A against A, TM-score 1.00
Q8IUD6 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase RNF135 (Q8IUD6) · a predicted model of the same protein · chain B against A, TM-score 0.98
O95786 · AlphaFold monomer V2.0 prediction for antiviral innate immune response receptor rig-I… · a predicted model of the same protein · chain A against A, TM-score 0.90

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O95786
Every structure of UniProt Q8IUD6
Elsewhere: RCSB PDB 7JL1 · PDBe 7JL1 · UniProt O95786 · UniProt Q8IUD6

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