UniProt O95786

Antiviral innate immune response receptor RIG-I (O95786)

Antiviral innate immune response receptor RIG-I (UniProt O95786), EC 3.6.4.13: 68 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 208 pockets. Binding sites, druggability and experiment against…

UniProt: O95786
Protein: Antiviral innate immune response receptor RIG-I
EC: 3.6.4.13
Experimental structures: 68
Predicted models: 1
Ligands: 6
Pockets: 208 · 18 records with a druggable one

Structures

69 records of O95786 in the MolNFT archive: 68 experimental, 1 predicted.

Entry	Title	Method	Chains	Ligands	Pockets
2LWD	Solution structure of second CARD of human RIG-I	solution nmr	A	—	—
2LWD	Solution structure of second card of human rig-I	solution nmr	A	—	—
2LWE	Solution structure of mutant (T170E) second CARD of human RIG-I	solution nmr	A	—	—
2LWE	Solution structure of mutant (T170E) second card of human rig-I	solution nmr	A	—	—
2QFB	Crystal structure of the regulatory domain of human RIG-I with bound Zn	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2QFB	Crystal structure of the regulatory domain of human rig-I with bound zn	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2QFD	Crystal structure of the regulatory domain of human RIG-I with bound Hg	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2QFD	Crystal structure of the regulatory domain of human rig-I with bound hg	x-ray diffraction	A, B, C, D, E, F, G, H, I, J	—	—
2RMJ	Solution structure of RIG-I C-terminal domain	solution nmr	A	—	—
2RMJ	Solution structure of rig-I C-terminal domain	solution nmr	A	—	—
2YKG	Structural insights into RNA recognition by RIG-I	x-ray diffraction	A	—	—
2YKG	Structural insights into RNA recognition by rig-I	x-ray diffraction	A	—	—
3LRN	Crystal structure of human RIG-I CTD bound to a 14 bp GC 5' ppp dsRNA	x-ray diffraction	A, B	—	—
3LRN	Crystal structure of human rig-I ctd bound to a 14 bp gc 5' ppp dsrna	x-ray diffraction	A, B	—	—
3LRR	Crystal structure of human RIG-I CTD bound to a 12 bp AU rich 5' ppp dsRNA	x-ray diffraction	A, B	—	—
3LRR	Crystal structure of human rig-I ctd bound to a 12 bp au rich 5' ppp dsrna	x-ray diffraction	A, B	—	—
3NCU	Structural and functional insights into pattern recognition by the innate immune receptor RIG-I	x-ray diffraction	A, B	—	—
3NCU	Structural and functional insights into pattern recognition by the innate immune receptor rig-I	x-ray diffraction	A, B	—	—
3OG8	Crystal structure of human RIG-I CTD bound to a 14-bp blunt-ended dsRNA	x-ray diffraction	A, B	—	—
3OG8	Crystal structure of human rig-I ctd bound to a 14-bp blunt-ended dsrna	x-ray diffraction	A, B	—	—
3ZD6	Snapshot 1 of RIG-I scanning on RNA duplex	x-ray diffraction	A	—	—
3ZD6	Snapshot 1 of rig-I scanning on RNA duplex	x-ray diffraction	A	—	—
3ZD7	Snapshot 3 of RIG-I scanning on RNA duplex	x-ray diffraction	A	—	—
3ZD7	Snapshot 3 of rig-I scanning on RNA duplex	x-ray diffraction	A	—	—
4AY2	Capturing 5' tri-phosphorylated RNA duplex by RIG-I	x-ray diffraction	A	—	—
4AY2	Capturing 5' tri-phosphorylated RNA duplex by rig-I	x-ray diffraction	A	—	—
4BPB	Structural insights into RNA recognition by rig-I	x-ray diffraction	A	—	—
4BPB	Structural insights into RNA recognition by rig-I	x-ray diffraction	A	—	—
4NQK	Structure of an Ubiquitin complex	x-ray diffraction	A, B, C, D	—	—
4NQK	Structure of an ubiquitin complex	x-ray diffraction	A, B, C, D	—	—
4ON9	DECH box helicase domain	x-ray diffraction	A, B	—	—
4ON9	Dech box helicase domain	x-ray diffraction	A, B	—	—
4P4H	Caught-in-action signaling complex of RIG-I 2CARD domain and MAVS CARD domain	x-ray diffraction	A, B, C, D, E, F, G, H	—	—
4P4H	Caught-in-action signaling complex of rig-I 2CARD domain and mavs card domain	x-ray diffraction	A, B, C, D, E, F, G, H	—	—
5E3H	Structural Basis for RNA Recognition and Activation of RIG-I	x-ray diffraction	A	ZN, MG, ADP, BEF	10 (best 0.79)
5E3H	Structural basis for RNA recognition and activation of rig-I	x-ray diffraction	A	—	—
5F98	Crystal structure of RIG-I in complex with Cap-0 RNA	x-ray diffraction	A, C, E, G, I, K	ZN, MG	—
5F98	Crystal structure of rig-I in complex with cap-0 RNA	x-ray diffraction	A, C, E, G, I, K	—	—
5F9F	Crystal structure of RIG-I helicase-RD in complex with 24-mer blunt-end hairpin RNA	x-ray diffraction	A, C, E, G, I, K	ZN, MG	—
5F9F	Crystal structure of rig-I helicase-rd in complex with 24-mer blunt- end hairpin RNA	x-ray diffraction	A, C, E, G, I, K	—	—
5F9H	Crystal structure of RIG-I helicase-RD in complex with 24-mer 5' triphosphate hairpin RNA	x-ray diffraction	A, C, E, G, I, K	ZN, MG	—
5F9H	Crystal structure of rig-I helicase-rd in complex with 24-mer 5' triphosphate hairpin RNA	x-ray diffraction	A, C, E, G, I, K	—	—
6GPG	Structure of the RIG-I Singleton-Merten syndrome variant C268F	x-ray diffraction	A	ZN, MG	—
6GPG	Structure of the rig-I singleton-merten syndrome variant C268F	x-ray diffraction	A	ZN, MG	—
6KYV	Crystal Structure of RIG-I and hairpin RNA with G-U wobble base pairs	x-ray diffraction	B, D, F, H, J, L	ZN	20 (best 0.82)
6KYV	Crystal structure of rig-I and hairpin RNA with G-U wobble base pairs	x-ray diffraction	B, D, F, H, J, L	ZN	—
7BAH	Structure of RIG-I CTD bound to OH-RNA	x-ray diffraction	A, B	ZN	1 (best 0.71)
7BAH	Structure of rig-I ctd bound to oh-RNA	x-ray diffraction	A, B	ZN	—
7BAI	Structure of rig-I ctd (I875A) bound to P-RNA	x-ray diffraction	A, B, E	ZN	—
7JL1	Cryo-EM structure of RIG-I:dsRNA in complex with RIPLET PrySpry domain (monomer)	electron microscopy	A	ADP, ALF, MG, ZN	13 (best 0.83)
7JL1	Cryo-EM structure of rig-I:DSRNA in complex with riplet pryspry domain (monomer)	electron microscopy	A	ADP, ALF, MG, ZN	—
7JL3	Cryo-EM structure of RIG-I:dsRNA filament in complex with RIPLET PrySpry domain (trimer)	electron microscopy	A, C, E	ADP, ALF, MG, ZN	19 (best 0.83)
7JL3	Cryo-EM structure of rig-I:DSRNA filament in complex with riplet pryspry domain (trimer)	electron microscopy	A, C, E	ADP, ALF, MG, ZN	—
7MK1	Structure of a protein-modified aptamer complex	x-ray diffraction	A, B	ZN, MG	—
7MK1	Structure of a protein-modified aptamer complex	x-ray diffraction	A, B	ZN, MG	—
7TNX	Cryo-EM structure of RIG-I in complex with p3dsRNA	electron microscopy	A	ZN	10 (best 0.85)
7TNZ	Cryo-EM structure of RIG-I in complex with p1dsRNA	electron microscopy	A	ZN	9 (best 0.84)
7TO0	Cryo-EM structure of RIG-I in complex with OHdsRNA	electron microscopy	A	ZN	9 (best 0.83)
7TO1	Cryo-EM structure of RIG-I bound to the end of p3SLR30 (+ATP)	electron microscopy	A	ZN	10 (best 0.74)
7TO2	Cryo-EM structure of RIG-I bound to the internal sites of p3SLR30 (+ATP)	electron microscopy	A	ZN, MG, ADP	11 (best 0.82)

9 records more on the page itself.

Ligands

ZN · Zinc ion · in 30 records
MG · Magnesium ion · in 15 records
ADP · Adenosine-5'-diphosphate · in 8 records
ALF · Tetrafluoroaluminate ion · in 4 records
BEF · Beryllium trifluoride ion · in 1 record
GTP · Guanosine-5'-triphosphate · in 1 record

Experiment against prediction

3NCU chain A against the predicted model O95786: TM-score 0.98, RMSD 0.55 Å
3NCU chain A against the predicted model O95786: TM-score 0.98, RMSD 0.55 Å
3LRR chain B against the predicted model O95786: TM-score 0.98, RMSD 0.57 Å
3LRR chain B against the predicted model O95786: TM-score 0.98, RMSD 0.57 Å
3NCU chain B against the predicted model O95786: TM-score 0.98, RMSD 0.59 Å
3NCU chain B against the predicted model O95786: TM-score 0.98, RMSD 0.59 Å
3LRR chain A against the predicted model O95786: TM-score 0.98, RMSD 0.59 Å
3LRR chain A against the predicted model O95786: TM-score 0.98, RMSD 0.59 Å
7MK1 chain B against the predicted model O95786: TM-score 0.98, RMSD 0.66 Å
7MK1 chain B against the predicted model O95786: TM-score 0.98, RMSD 0.66 Å

Elsewhere

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