MolNFT v1 · #178721 · protein

Crystal structure of importin alpha 2 in complex with LSD1 nls

7JJM · Lysine-specific histone demethylase 1A: “Crystal structure of importin alpha 2 in complex with LSD1 nls”. X-ray diffraction, 1 ligand (CL), 1 pocket (best druggability 0.42). MolNFT v1 #178721 on GenesisL1: 3D structure, binding…

PDB: 7JJM
Type: protein
Length: 428 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lysine-specific histone demethylase 1A; Importin subunit alpha-1
EC: 1.14.99.66
UniProt: O60341, P52293
Ligands: CL
Pockets: 1 · best druggability 0.42

Structure

x-ray diffraction · 2 distinct chains · 74% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Lysine-specific histone demethylase 1A (EC 1.14.99.66)	protein	6	0% helix, 0% strand	O60341
B	Importin subunit alpha-1	protein	422	75% helix, 0% strand	P52293

Ligands and binding sites

CL · Chloride ion · ion · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	74	0.42	0.80	12	empty

Interfaces

1 interface between chains.

A–B · 538 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

7JJM · Crystal structure of Importin alpha 2 in complex with LSD1 NLS · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O60341
Every structure of UniProt P52293
Elsewhere: RCSB PDB 7JJM · PDBe 7JJM · UniProt O60341 · UniProt P52293

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