MolNFT v1 · #178458 · protein
Toxoplasma gondii dihydrofolate reductase thymidylate synthase (tgdhfr-ts) complexed with P39, NADPH and dump
7FGX: “Toxoplasma gondii dihydrofolate reductase thymidylate synthase (tgdhfr-ts) complexed with P39, NADPH and dump”. X-ray diffraction, 3 ligands (NDP, 4RI, UMP). MolNFT v1 #178458 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 7FGX
- Type
- protein
- Length
- 2,241 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q07422
- Ligands
- NDP, 4RI, UMP
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 560 | — | Q07422 |
| B | — | protein | 560 | — | Q07422 |
| C | — | protein | 558 | — | Q07422 |
| D | — | protein | 563 | — | Q07422 |
Ligands and binding sites
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · 4 copies · chains A, B, C, D
- 4RI · 6-hexyl-5-phenyl-pyrimidine-2,4-diamine · ligand · 4 copies · chains A, B, C, D
- UMP · 2'-deoxyuridine 5'-monophosphate · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- Q07422 · AlphaFold monomer V2.0 prediction for bifunctional dihydrofolate reductase-thymidylate… · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07422
- Elsewhere: RCSB PDB 7FGX · PDBe 7FGX · UniProt Q07422
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