Toxoplasma gondii prolyl-tRNA synthetase (tgprs) in complex with inhibitor T35 and halofuginone

Structure

x-ray diffraction · 2 distinct chains.

Ligands and binding sites

• 1TI · 4-[(3S)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide · ligand · 2 copies · chains A, B
• HFG · 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one · ligand · 2 copies · chains A, B
• IOD · Iodide ion · ion · 10 copies · chains A, B
• BR · Bromide ion · ion · 6 copies · chains A, B
• F · Fluoride ion · ion · 3 copies · chains A, B
• MES · 2-(N-morpholino)-ethanesulfonic acid · additive · chains A, B
• BME · Beta-mercaptoethanol · additive · chains A
• GOL · Glycerol · additive · chains B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 7F9V · Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor T35 and… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt A0A7J6JUK2
• Elsewhere: RCSB PDB 7F9V · PDBe 7F9V · UniProt A0A7J6JUK2