MolNFT v1 · #177941 · protein

The structure of the human METTL6 enzyme in complex with sah

7EZG · TRNA N(3)-methylcytidine methyltransferase METTL6: “The structure of the human METTL6 enzyme in complex with sah”. X-ray diffraction, 1 ligand (SAH), 2 pockets (best druggability 0.76). MolNFT v1 #177941 on GenesisL1: 3D structure…

PDB: 7EZG
Type: protein
Length: 275 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: TRNA N(3)-methylcytidine methyltransferase METTL6
EC: 2.1.1.-
UniProt: Q8TCB7
Ligands: SAH
Pockets: 2 · best druggability 0.76

Structure

x-ray diffraction · 1 distinct chain · 36% helix, 25% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	TRNA N(3)-methylcytidine methyltransferase METTL6 (EC 2.1.1.-)	protein	275	36% helix, 25% strand	Q8TCB7

Ligands and binding sites

SAH · S-adenosyl-L-homocysteine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	691	0.76	0.81	81	SAH
2	73	0.48	0.83	15	empty

Compared structures

7EZG · The structure of the human METTL6 enzyme in complex with SAH · the same entry in another collection · chain A against A, TM-score 1.00
Q8TCB7 · AlphaFold monomer V2.0 prediction for tRNA N(3)-methylcytidine methyltransferase METTL6… · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8TCB7
Elsewhere: RCSB PDB 7EZG · PDBe 7EZG · UniProt Q8TCB7

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