UniProt Q8TCB7
tRNA N(3)-methylcytidine methyltransferase METTL6 (Q8TCB7)
tRNA N(3)-methylcytidine methyltransferase METTL6 (UniProt Q8TCB7), EC 2.1.1.-: 9 experimental structures and 1 predicted model on GenesisL1, 2 ligands bound, 23 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q8TCB7
- Protein
- tRNA N(3)-methylcytidine methyltransferase METTL6
- EC
- 2.1.1.-
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 2
- Pockets
- 23 · 7 records with a druggable one
Structures
10 records of Q8TCB7 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7EZG | The structure of the human METTL6 enzyme in complex with SAH | x-ray diffraction | A | SAH | 2 (best 0.76) |
| 7EZG | The structure of the human METTL6 enzyme in complex with sah | x-ray diffraction | A | — | — |
| 7F1E | Structure of METTL6 bound with SAM | x-ray diffraction | A, B | SAM | 4 (best 0.67) |
| 7F1E | Structure of METTL6 bound with SAM | x-ray diffraction | A, B | — | — |
| 8OWX | Crystal Structure of METTL6 bound to SAH | x-ray diffraction | A, B | SAH | 4 (best 0.73) |
| 8OWY | Crystal structure of METTL6 mutant 40-269 bound to SAH | x-ray diffraction | A, B | SAH | 3 (best 0.69) |
| 8P7B | CryoEM structure of METTL6 tRNA SerRS complex in a 1:2:2 stoichiometry | electron microscopy | A | SAH | 3 (best 0.78) |
| 8P7C | CryoEM structure of METTL6 tRNA SerRS complex in a 2:2:2 stoichiometry | electron microscopy | A, C | SAH | 5 (best 0.80) |
| 8P7D | CryoEM structure of METTL6 tRNA SerRS complex in a 1:1:2 stoichiometry | electron microscopy | A | SAH | 2 (best 0.80) |
| Q8TCB7 | AlphaFold monomer V2.0 prediction for tRNA N(3)-methylcytidine methyltransferase METTL6 (Q8TCB7) | predicted | A | — | — |
Ligands
Experiment against prediction
- 8P7D chain A against the predicted model Q8TCB7: TM-score 0.98, RMSD 0.92 Å
- 8P7B chain A against the predicted model Q8TCB7: TM-score 0.98, RMSD 0.92 Å
- 8P7C chain A against the predicted model Q8TCB7: TM-score 0.98, RMSD 0.92 Å
- 8P7C chain C against the predicted model Q8TCB7: TM-score 0.98, RMSD 0.93 Å
- 7F1E chain B against the predicted model Q8TCB7: TM-score 0.98, RMSD 0.93 Å
- 7F1E chain B against the predicted model Q8TCB7: TM-score 0.97, RMSD 0.93 Å
- 8OWX chain A against the predicted model Q8TCB7: TM-score 0.97, RMSD 1.15 Å
- 8OWY chain A against the predicted model Q8TCB7: TM-score 0.96, RMSD 1.24 Å
- 8OWY chain B against the predicted model Q8TCB7: TM-score 0.94, RMSD 1.55 Å
- 8OWX chain B against the predicted model Q8TCB7: TM-score 0.93, RMSD 1.31 Å
Elsewhere
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