Research workbench
The structure of the human METTL6 enzyme in complex with sah
Analyse The structure of the human METTL6 enzyme in complex with sah in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7EZG
- Type
- protein
- Length
- 275 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- TRNA N(3)-methylcytidine methyltransferase METTL6
- EC
- 2.1.1.-
- UniProt
- Q8TCB7
- Ligands
- SAH
- Pockets
- 2 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 36% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | TRNA N(3)-methylcytidine methyltransferase METTL6 (EC 2.1.1.-) | protein | 275 | 36% helix, 25% strand | Q8TCB7 |
Ligands and binding sites
- SAH · S-adenosyl-L-homocysteine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 691 | 0.76 | 0.81 | 81 | SAH |
| 2 | 73 | 0.48 | 0.83 | 15 | empty |
Compared structures
- 7EZG · The structure of the human METTL6 enzyme in complex with SAH · the same entry in another collection · chain A against A, TM-score 1.00
- Q8TCB7 · AlphaFold monomer V2.0 prediction for tRNA N(3)-methylcytidine methyltransferase METTL6… · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8TCB7
- Elsewhere: RCSB PDB 7EZG · PDBe 7EZG · UniProt Q8TCB7
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