MolNFT v1 · #177850 · protein
FZD7 -gs complex
7EVW · Mingas: “FZD7 -gs complex”. Electron microscopy, 13 pockets (best druggability 0.84). MolNFT v1 #177850 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EVW
- Type
- protein
- Length
- 1,094 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mingas; Ggamma; NB35; Frizzled-7; Guanine nucleotide-binding protein G(I)/G(S)/G(T)…
- UniProt
- O75084, P62873
- Pockets
- 13 · best druggability 0.84
Structure
electron microscopy · 5 distinct chains · 35% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mingas | protein | 234 | 46% helix, 16% strand | — |
| C | Ggamma | protein | 57 | 53% helix, 0% strand | — |
| N | NB35 | protein | 126 | 5% helix, 45% strand | — |
| R | Frizzled-7 | protein | 340 | 65% helix, 1% strand | O75084 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 337 | 7% helix, 45% strand | P62873 |
Pockets
13 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 818 | 0.84 | 0.87 | 90 | empty |
| 2 | 631 | 0.81 | 0.86 | 53 | empty |
| 3 | 109 | 0.78 | 0.97 | 23 | empty |
| 4 | 901 | 0.75 | 0.78 | 58 | empty |
| 5 | 401 | 0.72 | 0.83 | 61 | empty |
Interfaces
5 interfaces between chains.
- C–B · 2103 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 1524 Ų buried · 22 hydrogen bonds · protein-protein
- A–N · 881 Ų buried · 9 hydrogen bonds · protein-protein
- A–R · 682 Ų buried · 4 hydrogen bonds · protein-protein
- N–B · 580 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 5 disulfide (disulfide).
Compared structures
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- O75084 · AlphaFold monomer V2.0 prediction for frizzled-7 (O75084) · a predicted model of the same protein · chain R against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75084
- Every structure of UniProt P62873
- Elsewhere: RCSB PDB 7EVW · PDBe 7EVW · UniProt O75084 · UniProt P62873
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