UniProt O75084
Frizzled-7 (O75084)
Frizzled-7 (UniProt O75084): 19 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- O75084
- Protein
- Frizzled-7
- Experimental structures
- 19
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 26 · 6 records with a druggable one
Structures
20 records of O75084 in the MolNFT archive: 19 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5T44 | Crystal structure of Frizzled 7 CRD | x-ray diffraction | A, B | — | 1 (best 0.65) |
| 5T44 | Crystal structure of frizzled 7 crd | x-ray diffraction | A, B | — | — |
| 5URV | Crystal structure of Frizzled 7 CRD in complex with C24 fatty acid | x-ray diffraction | A, B | NER, NAG, SO4, 1PG | 1 (best 0.68) |
| 5URV | Crystal structure of frizzled 7 crd in complex with C24 fatty acid | x-ray diffraction | A, B | NER, NAG, SO4, 1PG | — |
| 5WBS | Crystal structure of Frizzled-7 CRD with an inhibitor peptide Fz7-21 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 5WBS | Crystal structure of frizzled-7 crd with an inhibitor peptide FZ7-21 | x-ray diffraction | A, B, C, D, E, F, G, H | — | — |
| 6NE2 | Designed repeat protein in complex with Fz7 | x-ray diffraction | A | NAG, SO4 | 2 (best 0.37) |
| 6NE2 | Designed repeat protein in complex with FZ7 | x-ray diffraction | A | NAG, SO4 | — |
| 6NE4 | Designed repeat protein specifically in complex with Fz7CRD | x-ray diffraction | A | SO4 | — |
| 6NE4 | Designed repeat protein specifically in complex with FZ7CRD | x-ray diffraction | A | SO4 | — |
| 6O3A | Crystal structure of Frizzled 7 CRD in complex with F7.B Fab | x-ray diffraction | E | NAG | — |
| 6O3A | Crystal structure of frizzled 7 crd in complex with F7.B Fab | x-ray diffraction | E | NAG | — |
| 6O3B | Crystal structure of Frizzled 7 CRD in complex with F6 Fab | x-ray diffraction | C, H | NAG | — |
| 6O3B | Crystal structure of frizzled 7 crd in complex with F6 Fab | x-ray diffraction | C, H | NAG | — |
| 7EVW | FZD7 -gs complex | electron microscopy | R | — | — |
| 8QEO | cryo-EM structure complex of Frizzled-7 and Clostridioides difficile toxin B | electron microscopy | B | — | 1 (best 0.52) |
| 8YY8 | Fzd7 -Gs complex | electron microscopy | R | — | 4 (best 0.83) |
| 9EPO | High resolution structure of FZD7 in inactive conformation | electron microscopy | A, D | Y01, PLM | 13 (best 0.83) |
| 9EW2 | High resolution structure of FZD7 in complex with miniGs protein | electron microscopy | R | — | 4 (best 0.81) |
| O75084 | AlphaFold monomer V2.0 prediction for frizzled-7 (O75084) | predicted | A | — | — |
Ligands
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 8 records
- SO4 · Sulfate ion · in 6 records
- 1PG · 2-(2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethanol · in 2 records
- NER · (15E)-tetracos-15-enoic acid · in 2 records
- PLM · Palmitic acid · in 1 record
- Y01 · Cholesterol hemisuccinate · in 1 record
Experiment against prediction
- 5URV chain A against the predicted model O75084: TM-score 0.99, RMSD 0.52 Å
- 5URV chain A against the predicted model O75084: TM-score 0.99, RMSD 0.52 Å
- 5T44 chain B against the predicted model O75084: TM-score 0.98, RMSD 0.63 Å
- 5T44 chain B against the predicted model O75084: TM-score 0.98, RMSD 0.63 Å
- 9EPO chain A against the predicted model O75084: TM-score 0.98, RMSD 1.11 Å
- 9EPO chain D against the predicted model O75084: TM-score 0.98, RMSD 1.11 Å
- 5T44 chain A against the predicted model O75084: TM-score 0.98, RMSD 0.70 Å
- 5T44 chain A against the predicted model O75084: TM-score 0.98, RMSD 0.70 Å
- 6O3A chain E against the predicted model O75084: TM-score 0.97, RMSD 0.80 Å
- 6O3A chain E against the predicted model O75084: TM-score 0.97, RMSD 0.80 Å
Elsewhere
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