MolNFT v1 · #177681 · protein

Co-crystal structure analysis of annexin A2 and 5ALPHA-eal

7EQ7: “Co-crystal structure analysis of annexin A2 and 5ALPHA-eal”. X-ray diffraction, 1 ligand (CA), 3 pockets (best druggability 0.49). MolNFT v1 #177681 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 7EQ7
Type: protein
Length: 318 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin A2
UniProt: P07355
Ligands: CA
Pockets: 3 · best druggability 0.49

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Annexin A2	protein	318	72% helix, 0% strand	P07355

Ligands and binding sites

CA · Calcium ion · metal · 2 copies · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	99	0.49	0.82	21	empty
2	162	0.49	0.78	34	empty
3	73	0.32	0.75	18	empty

Compared structures

7EQ7 · Co-Crystal Structure Analysis of Annexin A2 and 5alpha-EAL · the same entry in another collection · chain A against A, TM-score 1.00
P07355 · AlphaFold monomer V2.0 prediction for annexin A2 (P07355) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07355
Elsewhere: RCSB PDB 7EQ7 · PDBe 7EQ7 · UniProt P07355

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