MolNFT v1 · #177638 · protein
Structure of the human GLUN1/GLUN2A NMDA receptor in the GLYCINE/GLUTAMATE/GNE-6901/9-aa bound state
7EOU: “Structure of the human GLUN1/GLUN2A NMDA receptor in the GLYCINE/GLUTAMATE/GNE-6901/9-aa bound state”. Electron microscopy, 3 ligands (6RM, AA, NAG). MolNFT v1 #177638 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EOU
- Type
- protein
- Length
- 3,084 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q12879, Q05586
- Ligands
- 6RM, AA, NAG
Structure
electron microscopy · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | — | protein | 759 | — | Q12879 |
| B, D | — | protein | 783 | — | Q05586 |
Ligands and binding sites
- 6RM · 7-[(4-fluoranylphenoxy)methyl]-3-[(1~{R},2~{R})-2-(hydroxymethyl)cyclopropyl]-2-methyl-[1,3]thiazolo[3, 2-a]pyrimidin-5-one · ligand · 2 copies · chains A, B, C, D
- AA · 9-aminoacridine · ligand
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 16 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7EOU · Structure of the human GluN1/GluN2A NMDA receptor in the glycine/glutamate/GNE-6901/9-AA… · the same entry in another collection · chain A against A, TM-score 1.00
- Q05586 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 1 (Q05586) · a predicted model of the same protein · chain B against A, TM-score 0.95
- Q12879 · AlphaFold monomer V2.0 prediction for glutamate receptor ionotropic, NMDA 2A (Q12879) · a predicted model of the same protein · chain A against A, TM-score 0.88
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q12879
- Every structure of UniProt Q05586
- Elsewhere: RCSB PDB 7EOU · PDBe 7EOU · UniProt Q12879 · UniProt Q05586
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