MolNFT v1 · #177215 · protein
The structure of the A20-binding inhibitor of nf-kb 1 in complex with tetra-ubiquitin
7EB9 · Tetra ubiquitin: “The structure of the A20-binding inhibitor of nf-kb 1 in complex with tetra-ubiquitin”. X-ray diffraction, 1 pocket (best druggability 0.34). MolNFT v1 #177215 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 7EB9
- Type
- protein
- Length
- 413 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tetra ubiquitin; TNFAIP3-interacting protein 1
- UniProt
- P0CG48, Q15025
- Pockets
- 1 · best druggability 0.34
Structure
x-ray diffraction · 3 distinct chains · 41% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tetra ubiquitin | protein | 299 | 22% helix, 32% strand | P0CG48 |
| B | TNFAIP3-interacting protein 1 | protein | 54 | 93% helix, 0% strand | Q15025 |
| C | TNFAIP3-interacting protein 1 | protein | 60 | 92% helix, 0% strand | Q15025 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 107 | 0.34 | 0.73 | 22 | empty |
Interfaces
3 interfaces between chains.
- B–C · 1554 Ų buried · 13 hydrogen bonds · protein-protein
- A–B · 829 Ų buried · 14 hydrogen bonds · protein-protein
- A–C · 533 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7EB9 · The structure of the A20-binding inhibitor of NF-kB 1 in complex with tetra-ubiquitin · the same entry in another collection · chain A against A, TM-score 1.00
- Q15025 · AlphaFold monomer V2.0 prediction for TNFAIP3-interacting protein 1 (Q15025) · a predicted model of the same protein · chain C against A, TM-score 0.91
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0CG48
- Every structure of UniProt Q15025
- Elsewhere: RCSB PDB 7EB9 · PDBe 7EB9 · UniProt P0CG48 · UniProt Q15025
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