MolNFT v1 · #177128 · protein

Cryoem structure of human KV4.2-DPP6S-KCHIP1 complex, transmembrane and intracellular region

7E8E · Kv channel-interacting protein 1: “Cryoem structure of human KV4.2-DPP6S-KCHIP1 complex, transmembrane and intracellular region”. Electron microscopy, 20 pockets (best druggability 0.86). MolNFT v1 #177128 on GenesisL1: 3D…

PDB: 7E8E
Type: protein
Length: 2,662 residues
Chains: 12
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Kv channel-interacting protein 1; Potassium voltage-gated channel subfamily D member 2…
UniProt: Q9NZI2, Q9NZV8, P42658
Pockets: 20 · best druggability 0.86

Structure

electron microscopy · 6 distinct chains · 63% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
G, E	Kv channel-interacting protein 1	protein	177	57% helix, 4% strand	Q9NZI2
C, A	Potassium voltage-gated channel subfamily D member 2	protein	460	61% helix, 3% strand	Q9NZV8
K, I	Dipeptidyl aminopeptidase-like protein 6	protein	31	87% helix, 0% strand	P42658
H, F	Kv channel-interacting protein 1	protein	176	60% helix, 2% strand	Q9NZI2
D, B	Potassium voltage-gated channel subfamily D member 2	protein	459	65% helix, 3% strand	Q9NZV8
L, J	Dipeptidyl aminopeptidase-like protein 6	protein	28	86% helix, 0% strand	P42658

Pockets

20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	759	0.86	0.90	76	empty
2	782	0.81	0.84	46	empty
3	1054	0.77	0.79	101	empty
4	1060	0.77	0.79	98	empty
5	1043	0.77	0.78	99	empty

Interfaces

18 interfaces between chains.

C–B · 3354 Å² buried · 23 hydrogen bonds · protein-protein
D–A · 3342 Å² buried · 24 hydrogen bonds · protein-protein
A–B · 3276 Å² buried · 22 hydrogen bonds · protein-protein
C–D · 3255 Å² buried · 23 hydrogen bonds · protein-protein
D–E · 1925 Å² buried · 10 hydrogen bonds · protein-protein

Compared structures

7E8E · CryoEM structure of human Kv4.2-DPP6S-KChIP1 complex, transmembrane and intracellular… · the same entry in another collection · chain J against J, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9NZI2
Every structure of UniProt Q9NZV8
Every structure of UniProt P42658
Elsewhere: RCSB PDB 7E8E · PDBe 7E8E · UniProt Q9NZI2 · UniProt Q9NZV8 · UniProt P42658

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