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Cryoem structure of human KV4.2-DPP6S-KCHIP1 complex, transmembrane and intracellular region
Analyse Cryoem structure of human KV4.2-DPP6S-KCHIP1 complex, transmembrane and… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 7E8E
- Type
- protein
- Length
- 2,662 residues
- Chains
- 12
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kv channel-interacting protein 1; Potassium voltage-gated channel subfamily D member 2…
- UniProt
- Q9NZI2, Q9NZV8, P42658
- Pockets
- 20 · best druggability 0.86
Structure
electron microscopy · 6 distinct chains · 63% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| G, E | Kv channel-interacting protein 1 | protein | 177 | 57% helix, 4% strand | Q9NZI2 |
| C, A | Potassium voltage-gated channel subfamily D member 2 | protein | 460 | 61% helix, 3% strand | Q9NZV8 |
| K, I | Dipeptidyl aminopeptidase-like protein 6 | protein | 31 | 87% helix, 0% strand | P42658 |
| H, F | Kv channel-interacting protein 1 | protein | 176 | 60% helix, 2% strand | Q9NZI2 |
| D, B | Potassium voltage-gated channel subfamily D member 2 | protein | 459 | 65% helix, 3% strand | Q9NZV8 |
| L, J | Dipeptidyl aminopeptidase-like protein 6 | protein | 28 | 86% helix, 0% strand | P42658 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 759 | 0.86 | 0.90 | 76 | empty |
| 2 | 782 | 0.81 | 0.84 | 46 | empty |
| 3 | 1054 | 0.77 | 0.79 | 101 | empty |
| 4 | 1060 | 0.77 | 0.79 | 98 | empty |
| 5 | 1043 | 0.77 | 0.78 | 99 | empty |
Interfaces
18 interfaces between chains.
- C–B · 3354 Ų buried · 23 hydrogen bonds · protein-protein
- D–A · 3342 Ų buried · 24 hydrogen bonds · protein-protein
- A–B · 3276 Ų buried · 22 hydrogen bonds · protein-protein
- C–D · 3255 Ų buried · 23 hydrogen bonds · protein-protein
- D–E · 1925 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
- 7E8E · CryoEM structure of human Kv4.2-DPP6S-KChIP1 complex, transmembrane and intracellular… · the same entry in another collection · chain J against J, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9NZI2
- Every structure of UniProt Q9NZV8
- Every structure of UniProt P42658
- Elsewhere: RCSB PDB 7E8E · PDBe 7E8E · UniProt Q9NZI2 · UniProt Q9NZV8 · UniProt P42658
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