MolNFT v1 · #176556 · protein
The structure of the arabidopsis thaliana guanosine deaminase mutant Y185F complexed with guanosine
7DQN: “The structure of the arabidopsis thaliana guanosine deaminase mutant Y185F complexed with guanosine”. X-ray diffraction, 2 ligands (GMP, ZN), 3 pockets (best druggability 0.77). MolNFT v1 #176556 on GenesisL1: 3D structure, binding…
- PDB
- 7DQN
- Type
- protein
- Length
- 313 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Guanosine deaminase
- EC
- 3.5.4.15
- UniProt
- Q94BU8
- Ligands
- GMP, ZN
- Pockets
- 3 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Guanosine deaminase (EC 3.5.4.15) | protein | 157 | 43% helix, 17% strand | Q94BU8 |
| D | Guanosine deaminase (EC 3.5.4.15) | protein | 156 | 44% helix, 19% strand | Q94BU8 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 123 | 0.77 | 0.95 | 25 | GMP |
| 2 | 209 | 0.65 | 0.84 | 28 | empty |
| 3 | 61 | 0.29 | 0.74 | 13 | empty |
Interfaces
1 interface between chains.
- A–D · 1598 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 7DQN · The structure of the Arabidopsis thaliana guanosine deaminase mutant Y185F complexed with… · the same entry in another collection · chain A against A, TM-score 1.00
- Q94BU8 · AlphaFold monomer V2.0 prediction for guanosine deaminase (Q94BU8) · a predicted model of the same protein · chain A against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q94BU8
- Elsewhere: RCSB PDB 7DQN · PDBe 7DQN · UniProt Q94BU8
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