MolNFT v1 · #176336 · protein

Crystal structure of the G26C/Q250A mutant of leut

7DJC · NA(+):NEUROTRANSMITTER symporter (snf family): “Crystal structure of the G26C/Q250A mutant of leut”. X-ray diffraction, 2 ligands (LEU, NA), 4 pockets (best druggability 0.70). MolNFT v1 #176336 on GenesisL1: 3D structure, binding…

PDB: 7DJC
Type: protein
Length: 488 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NA(+):NEUROTRANSMITTER symporter (snf family)
UniProt: O67854
Ligands: LEU, NA
Pockets: 4 · best druggability 0.70

Structure

x-ray diffraction · 1 distinct chain · 78% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	NA(+):NEUROTRANSMITTER symporter (snf family)	protein	488	78% helix, 1% strand	O67854

Ligands and binding sites

LEU · Leucine · ligand · chains A
NA · Sodium ion · metal · 2 copies · chains A
BOG · octyl beta-D-glucopyranoside · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	458	0.70	0.80	48	empty
2	75	0.47	0.82	13	empty
3	63	0.39	0.78	11	empty
4	68	0.31	0.74	10	empty

Compared structures

7DJC · Crystal structure of the G26C/Q250A mutant of LeuT · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt O67854
Elsewhere: RCSB PDB 7DJC · PDBe 7DJC · UniProt O67854

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