MolNFT v1 · #176055 · protein
Cryo-EM structure of the human MCT1 D309N mutant in complex with basigin-2 in the inward-open conformation.
7DA5 · Monocarboxylate transporter 1: “Cryo-EM structure of the human MCT1 D309N mutant in complex with basigin-2 in the inward-open conformation.”. Electron microscopy, 5 pockets (best druggability 0.77). MolNFT v1 #176055 on GenesisL1…
- PDB
- 7DA5
- Type
- protein
- Length
- 591 residues
- Chains
- 2
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Monocarboxylate transporter 1; Basigin
- UniProt
- P53985, P35613
- Pockets
- 5 · best druggability 0.77
Structure
electron microscopy · 2 distinct chains · 57% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Monocarboxylate transporter 1 | protein | 375 | 80% helix, 0% strand | P53985 |
| B | Basigin | protein | 216 | 17% helix, 47% strand | P35613 |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 666 | 0.77 | 0.82 | 59 | empty |
| 2 | 407 | 0.71 | 0.83 | 71 | empty |
| 3 | 306 | 0.61 | 0.79 | 56 | empty |
| 4 | 142 | 0.45 | 0.76 | 25 | empty |
| 5 | 50 | 0.27 | 0.74 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 731 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 7DA5 · Cryo-EM structure of the human MCT1 D309N mutant in complex with Basigin-2 in the… · the same entry in another collection · chain A against A, TM-score 1.00
- P53985 · AlphaFold monomer V2.0 prediction for monocarboxylate transporter 1 (P53985) · a predicted model of the same protein · chain A against A, TM-score 0.97
- P35613 · AlphaFold monomer V2.0 prediction for basigin (P35613) · a predicted model of the same protein · chain B against A, TM-score 0.72
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P53985
- Every structure of UniProt P35613
- Elsewhere: RCSB PDB 7DA5 · PDBe 7DA5 · UniProt P53985 · UniProt P35613
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.