MolNFT v1 · #176000 · protein
CRTC1 PSER64 peptide in complex with 14-3-3 zeta
7D8H · 14-3-3 protein ZETA/DELTA: “CRTC1 PSER64 peptide in complex with 14-3-3 zeta”. X-ray diffraction, 1 pocket (best druggability 0.59). MolNFT v1 #176000 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7D8H
- Type
- protein
- Length
- 236 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 14-3-3 protein ZETA/DELTA; CRTC1 PSER64 peptide
- UniProt
- P63104, Q6UUV9
- Pockets
- 1 · best druggability 0.59
Structure
x-ray diffraction · 2 distinct chains · 78% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 14-3-3 protein ZETA/DELTA | protein | 230 | 80% helix, 0% strand | P63104 |
| B | CRTC1 PSER64 peptide | protein | 6 | 0% helix, 0% strand | Q6UUV9 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 225 | 0.59 | 0.80 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 460 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 7D8H · CRTC1 pSer64 peptide in complex with 14-3-3 zeta · the same entry in another collection · chain A against A, TM-score 1.00
- P63104 · AlphaFold monomer V2.0 prediction for 14-3-3 protein ZETA/DELTA (P63104) · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q6UUV9 · AlphaFold monomer V2.0 prediction for creb-regulated transcription coactivator 1 (Q6UUV9) · a predicted model of the same protein · chain B against A, TM-score 0.43
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63104
- Every structure of UniProt Q6UUV9
- Elsewhere: RCSB PDB 7D8H · PDBe 7D8H · UniProt P63104 · UniProt Q6UUV9
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