MolNFT v1 · #175008 · protein
Structure of GABARAPL1 in complex with GABA(A) receptor gamma 2
7CDB · Gamma-aminobutyric acid receptor-associated protein-like 1: “Structure of GABARAPL1 in complex with GABA(A) receptor gamma 2”. X-ray diffraction, 1 pocket (best druggability 0.70). MolNFT v1 #175008 on GenesisL1: 3D structure…
- PDB
- 7CDB
- Type
- protein
- Length
- 259 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Gamma-aminobutyric acid receptor-associated protein-like 1; Gamma-aminobutyric acid…
- UniProt
- Q8R3R8, P22723
- Pockets
- 1 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 31% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Gamma-aminobutyric acid receptor-associated protein-like 1 | protein | 122 | 31% helix, 21% strand | Q8R3R8 |
| C | Gamma-aminobutyric acid receptor subunit gamma-2 | protein | 15 | 27% helix, 13% strand | P22723 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 385 | 0.70 | 0.82 | 32 | CIT |
Interfaces
3 interfaces between chains.
- B–C · 747 Ų buried · 11 hydrogen bonds · protein-protein
- A–B · 342 Ų buried · 1 hydrogen bond · protein-protein
- A–C · 156 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 7CDB · Structure of GABARAPL1 in complex with GABA(A) receptor gamma 2 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8R3R8 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor-associated… · a predicted model of the same protein · chain B against A, TM-score 0.94
- P22723 · AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit gamma-2… · a predicted model of the same protein · chain C against A, TM-score 0.31
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8R3R8
- Every structure of UniProt P22723
- Elsewhere: RCSB PDB 7CDB · PDBe 7CDB · UniProt Q8R3R8 · UniProt P22723
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