UniProt P22723
Gamma-aminobutyric acid receptor subunit gamma-2 (P22723)
Gamma-aminobutyric acid receptor subunit gamma-2 (UniProt P22723): 9 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 58 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- P22723
- Protein
- Gamma-aminobutyric acid receptor subunit gamma-2
- Experimental structures
- 9
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 58 · 8 records with a druggable one
Structures
10 records of P22723 in the MolNFT archive: 9 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 7CDB | Structure of GABARAPL1 in complex with GABA(A) receptor gamma 2 | x-ray diffraction | C | — | 1 (best 0.70) |
| 7CDB | Structure of GABARAPL1 in complex with GABA(A) receptor gamma 2 | x-ray diffraction | C | — | — |
| 8FOI | Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA and… | electron microscopy | D | BMA, MAN, NAG, D12 | 8 (best 0.82) |
| 8G4N | Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with GABA… | electron microscopy | D | NAG, BMA, MAN, R5R, D12 | 8 (best 0.82) |
| 8G4O | Native GABA-A receptor from the mouse brain, alpha1-beta2-gamma2 subtype, in complex with… | electron microscopy | D | BMA, MAN, NAG, YNL | 7 (best 0.86) |
| 8G4X | Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | D | BMA, MAN, NAG | 9 (best 0.82) |
| 8G5F | Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | D | BMA, MAN, NAG | 8 (best 0.83) |
| 8G5G | Native GABA-A receptor from the mouse brain, meta-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | D | BMA, MAN, NAG, R5R | 9 (best 0.84) |
| 8G5H | Native GABA-A receptor from the mouse brain, ortho-alpha1-alpha3-beta2-gamma2 subtype, in complex… | electron microscopy | D | BMA, MAN, NAG, R5R | 8 (best 0.83) |
| P22723 | AlphaFold monomer V2.0 prediction for gamma-aminobutyric acid receptor subunit gamma-2 (P22723) | predicted | A | — | — |
Ligands
- BMA · beta-D-mannopyranose · in 7 records
- MAN · alpha-D-mannopyranose · in 7 records
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · in 7 records
- R5R · Zolpidem · in 3 records
- D12 · Dodecane · in 2 records
- YNL · (5M)-1-(2-aminoethyl)-7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one · in 1 record
Experiment against prediction
- 8FOI chain D against the predicted model P22723: TM-score 0.99, RMSD 0.77 Å
- 8G4N chain D against the predicted model P22723: TM-score 0.98, RMSD 0.89 Å
- 8G5H chain D against the predicted model P22723: TM-score 0.98, RMSD 1.01 Å
- 8G4O chain D against the predicted model P22723: TM-score 0.97, RMSD 1.11 Å
- 8G5F chain D against the predicted model P22723: TM-score 0.97, RMSD 1.14 Å
- 8G5G chain D against the predicted model P22723: TM-score 0.96, RMSD 1.27 Å
- 8G4X chain D against the predicted model P22723: TM-score 0.96, RMSD 1.28 Å
- 7CDB chain C against the predicted model P22723: TM-score 0.31, RMSD 2.01 Å
- 7CDB chain C against the predicted model P22723: TM-score 0.31, RMSD 2.01 Å
Elsewhere
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