MolNFT v1 · #174777 · protein
Crystal structure of AT2R-bril and SRP2070_FAB complex
7C6A · IgG light chain: “Crystal structure of AT2R-bril and SRP2070_FAB complex”. X-ray diffraction, 11 pockets (best druggability 0.54). MolNFT v1 #174777 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7C6A
- Type
- protein
- Length
- 811 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- IgG light chain; IgG heavy chain; Type-2 angiotensin II RECEPTOR,SOLUBLE cytochrome B562…
- UniProt
- P50052, P0ABE7
- Pockets
- 11 · best druggability 0.54
Structure
x-ray diffraction · 4 distinct chains · 40% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | IgG light chain | protein | 211 | 6% helix, 49% strand | — |
| H | IgG heavy chain | protein | 219 | 7% helix, 46% strand | — |
| A | Type-2 angiotensin II RECEPTOR,SOLUBLE cytochrome B562, type-2 angiotensin II receptor | protein | 373 | 79% helix, 3% strand | P50052, P0ABE7 |
| B | SAR1, ILE8-angiotensin II | protein | 8 | 0% helix, 13% strand | — |
Pockets
11 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 68 | 0.54 | 0.86 | 16 | empty |
| 2 | 205 | 0.50 | 0.76 | 32 | empty |
| 3 | 134 | 0.44 | 0.76 | 22 | empty |
| 4 | 126 | 0.43 | 0.77 | 24 | empty |
| 5 | 128 | 0.43 | 0.76 | 26 | empty |
Interfaces
4 interfaces between chains.
- L–H · 2040 Ų buried · 15 hydrogen bonds · protein-protein
- A–B · 934 Ų buried · 14 hydrogen bonds · protein-protein
- H–A · 766 Ų buried · 8 hydrogen bonds · protein-protein
- L–A · 375 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide, 1 modified (disulfide, methylation).
Compared structures
- 7C6A · Crystal structure of AT2R-BRIL and SRP2070_Fab complex · the same entry in another collection · chain L against L, TM-score 1.00
- P50052 · AlphaFold monomer V2.0 prediction for type-2 angiotensin II receptor (P50052) · a predicted model of the same protein · chain A against A, TM-score 0.74
- P0ABE7 · AlphaFold monomer V2.0 prediction for soluble cytochrome B562 (P0ABE7) · a predicted model of the same protein · chain A against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P50052
- Every structure of UniProt P0ABE7
- Elsewhere: RCSB PDB 7C6A · PDBe 7C6A · UniProt P50052 · UniProt P0ABE7
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