MolNFT v1 · #174596 · protein + DNA
Crystal structure of chimeric mutant of GH5 in complex with Z-DNA
7C0J · Histone H5,DOUBLE-stranded RNA-specific adenosine deaminase: “Crystal structure of chimeric mutant of GH5 in complex with Z-DNA”. X-ray diffraction, 1 pocket (best druggability 0.46). MolNFT v1 #174596 on GenesisL1: 3D structure…
- PDB
- 7C0J
- Type
- protein + DNA
- Length
- 133 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Histone H5,DOUBLE-stranded RNA-specific adenosine deaminase; DNA…
- UniProt
- P02259, P55265
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 3 distinct chains · 58% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Histone H5,DOUBLE-stranded RNA-specific adenosine deaminase | protein | 59 | 59% helix, 15% strand | P02259, P55265 |
| B | Histone H5,DOUBLE-stranded RNA-specific adenosine deaminase | protein | 62 | 56% helix, 15% strand | P02259, P55265 |
| D, E | DNA (5'-D(*TP*CP*GP*CP*GP*CP*G)-3') | dna | 6 | — | — |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 84 | 0.46 | 0.82 | 17 | empty |
Interfaces
6 interfaces between chains.
- A–D · 380 Ų buried · 5 hydrogen bonds · protein-nucleic
- B–E · 368 Ų buried · 4 hydrogen bonds · protein-nucleic
- D–E · 328 Ų buried · 32 hydrogen bonds · nucleic-nucleic
- A–E · 25 Ų buried · 0 hydrogen bonds · protein-nucleic
- A–B · 14 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
- 7C0J · Crystal structure of chimeric mutant of GH5 in complex with Z-DNA · the same entry in another collection · chain E against E, TM-score 1.00
- P02259 · AlphaFold monomer V2.0 prediction for histone H5 (P02259) · a predicted model of the same protein · chain B against A, TM-score 0.88
- P55265 · AlphaFold monomer V2.0 prediction for double-stranded RNA-specific adenosine deaminase… · a predicted model of the same protein · chain A against A, TM-score 0.79
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02259
- Every structure of UniProt P55265
- Elsewhere: RCSB PDB 7C0J · PDBe 7C0J · UniProt P02259 · UniProt P55265
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