UniProt P55265
Double-stranded RNA-specific adenosine deaminase (P55265)
Double-stranded RNA-specific adenosine deaminase (UniProt P55265), EC 3.5.4.37: 37 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 15 pockets. Binding sites, druggability and experiment against…
- UniProt
- P55265
- Protein
- Double-stranded RNA-specific adenosine deaminase
- EC
- 3.5.4.37
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 15 · 4 records with a druggable one
Structures
38 records of P55265 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1QBJ | Crystal structure of the zalpha Z-DNA complex | x-ray diffraction | A, B, C | — | — |
| 1QBJ | Crystal structure of the zalpha Z-DNA complex | x-ray diffraction | A, B, C | — | — |
| 1QGP | NMR structure of the Z-alpha domain of ADAR1, 15 structures | solution nmr | A | — | — |
| 1QGP | NMR structure of the Z-alpha domain of ADAR1, 15 structures | solution nmr | A | — | — |
| 1XMK | The Crystal structure of the Zb domain from the RNA editing enzyme ADAR1 | x-ray diffraction | A | — | — |
| 1XMK | The crystal structure of the zb domain from the RNA editing enzyme ADAR1 | x-ray diffraction | A | — | — |
| 2ACJ | Crystal structure of the B/Z junction containing DNA bound to Z-DNA binding proteins | x-ray diffraction | A, B, C, D | — | — |
| 2ACJ | Crystal structure of the B/Z junction containing DNA bound to Z-DNA binding proteins | x-ray diffraction | A, B, C, D | — | — |
| 2GXB | Crystal Structure of The Za Domain bound to Z-RNA | x-ray diffraction | A, B | — | — |
| 2GXB | Crystal structure of the za domain bound to Z-RNA | x-ray diffraction | A, B | — | — |
| 2L54 | Solution structure of the Zalpha domain mutant of ADAR1 (N43A,Y47A) | solution nmr | A | — | — |
| 2L54 | Solution structure of the zalpha domain mutant of ADAR1 (N43A,Y47A) | solution nmr | A | — | — |
| 2MDR | Solution structure of the third double-stranded RNA-binding domain (dsRBD3) of human… | solution nmr | A | — | — |
| 2MDR | Solution structure of the third double-stranded RNA-binding domain (DSRBD3) of human… | solution nmr | A | — | — |
| 3F21 | Crystal structure of Zalpha in complex with d(CACGTG) | x-ray diffraction | A, B, C | — | — |
| 3F21 | Crystal structure of zalpha in complex with D(CACGTG) | x-ray diffraction | A, B, C | — | — |
| 3F22 | Crystal structure of Zalpha in complex with d(CGTACG) | x-ray diffraction | A, B, C | — | — |
| 3F22 | Crystal structure of zalpha in complex with D(CGTACG) | x-ray diffraction | A, B, C | — | — |
| 3F23 | Crystal structure of Zalpha in complex with d(CGGCCG) | x-ray diffraction | A, B, C | — | — |
| 3F23 | Crystal structure of zalpha in complex with D(CGGCCG) | x-ray diffraction | A, B, C | — | — |
| 3IRQ | Crystal structure of a Z-Z junction | x-ray diffraction | D, C, B, A | — | — |
| 3IRQ | Crystal structure of a Z-Z junction | x-ray diffraction | D, C, B, A | — | — |
| 3IRR | Crystal Structure of a Z-Z junction (with HEPES intercalating) | x-ray diffraction | A, B, C, D | — | — |
| 3IRR | Crystal structure of a Z-Z junction (with hepes intercalating) | x-ray diffraction | A, B, C, D | — | — |
| 5ZU1 | Crystal Structure of BZ junction in diverse sequence | x-ray diffraction | A, B, C, D | — | 4 (best 0.69) |
| 5ZU1 | Crystal structure of bz junction in diverse sequence | x-ray diffraction | A, B, C, D | — | — |
| 5ZUO | Crystal Structure of BZ junction in diverse sequence | x-ray diffraction | A, B, C, D | — | 3 (best 0.70) |
| 5ZUO | Crystal structure of bz junction in diverse sequence | x-ray diffraction | A, B, C, D | — | — |
| 5ZUP | Crystal Structure of BZ junction in diverse sequence | x-ray diffraction | A, B, C, D | — | 3 (best 0.71) |
| 5ZUP | Crystal structure of bz junction in diverse sequence | x-ray diffraction | A, B, C, D | — | — |
| 7C0I | Crystal structure of chimeric mutant of E3L in complex with Z-DNA | x-ray diffraction | A, B, C | SO4 | 2 (best 0.43) |
| 7C0I | Crystal structure of chimeric mutant of E3L in complex with Z-DNA | x-ray diffraction | A, B, C | SO4 | — |
| 7C0J | Crystal structure of chimeric mutant of GH5 in complex with Z-DNA | x-ray diffraction | A, B | — | 1 (best 0.46) |
| 7C0J | Crystal structure of chimeric mutant of GH5 in complex with Z-DNA | x-ray diffraction | A, B | — | — |
| 7ZLQ | Crystal structure of ADAR1-dsRBD3 dimer in complex with dsRNA | x-ray diffraction | A, B | — | 2 (best 0.51) |
| 8GBC | Homo sapiens Zalpha mutant - N173S | solution nmr | A | — | — |
| 8GBD | Homo sapiens Zalpha mutant - P193A | solution nmr | A | — | — |
| P55265 | AlphaFold monomer V2.0 prediction for double-stranded RNA-specific adenosine deaminase (P55265) | predicted | A | — | — |
Ligands
- SO4 · Sulfate ion · in 2 records
Experiment against prediction
- 3IRR chain C against the predicted model P55265: TM-score 0.97, RMSD 0.45 Å
- 3IRR chain C against the predicted model P55265: TM-score 0.97, RMSD 0.45 Å
- 1QBJ chain B against the predicted model P55265: TM-score 0.97, RMSD 0.49 Å
- 1QBJ chain B against the predicted model P55265: TM-score 0.97, RMSD 0.49 Å
- 3F22 chain A against the predicted model P55265: TM-score 0.97, RMSD 0.51 Å
- 3F22 chain A against the predicted model P55265: TM-score 0.97, RMSD 0.51 Å
- 3F23 chain A against the predicted model P55265: TM-score 0.97, RMSD 0.51 Å
- 3F23 chain A against the predicted model P55265: TM-score 0.97, RMSD 0.51 Å
- 1QBJ chain A against the predicted model P55265: TM-score 0.97, RMSD 0.53 Å
- 1QBJ chain A against the predicted model P55265: TM-score 0.97, RMSD 0.53 Å
Elsewhere
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