MolNFT v1 · #174469 · protein
Cryo-EM structure for the ectodomain of the full-length human insulin receptor in complex with 2 insulin
7BWA: “Cryo-EM structure for the ectodomain of the full-length human insulin receptor in complex with 2 insulin”. Electron microscopy, 20 pockets (best druggability 0.81). MolNFT v1 #174469 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7BWA
- Type
- protein
- Length
- 1,444 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin receptor; Insulin fusion
- EC
- 2.7.10.1
- UniProt
- P06213, P01308
- Pockets
- 20 · best druggability 0.81
Structure
electron microscopy · 2 distinct chains · 14% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Insulin receptor (EC 2.7.10.1) | protein | 674 | 12% helix, 26% strand | P06213 |
| D, E | Insulin fusion | protein | 48 | 42% helix, 0% strand | P01308 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 163 | 0.81 | 0.96 | 34 | empty |
| 2 | 160 | 0.80 | 0.95 | 32 | empty |
| 3 | 190 | 0.79 | 0.93 | 50 | empty |
| 4 | 321 | 0.78 | 0.88 | 74 | empty |
| 5 | 118 | 0.76 | 0.95 | 38 | empty |
Interfaces
5 interfaces between chains.
- A–C · 1767 Ų buried · 6 hydrogen bonds · protein-protein
- C–D · 730 Ų buried · 6 hydrogen bonds · protein-protein
- A–E · 701 Ų buried · 11 hydrogen bonds · protein-protein
- A–D · 434 Ų buried · 2 hydrogen bonds · protein-protein
- C–E · 212 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 32 disulfide (disulfide).
Compared structures
- 7BWA · Cryo-EM Structure for the Ectodomain of the Full-length Human Insulin Receptor in Complex… · the same entry in another collection · chain C against C, TM-score 1.00
- P06213 · AlphaFold monomer V2.0 prediction for insulin receptor (P06213) · a predicted model of the same protein · chain A against A, TM-score 0.53
- P01308 · AlphaFold monomer V2.0 prediction for insulin (P01308) · a predicted model of the same protein · chain E against A, TM-score 0.30
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06213
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 7BWA · PDBe 7BWA · UniProt P06213 · UniProt P01308
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