MolNFT v1 · #174109 · protein
BAZ2A bromodomain in complex with tp-238 chemical probe
7BLA · Bromodomain adjacent to zinc finger domain protein 2A: “BAZ2A bromodomain in complex with tp-238 chemical probe”. X-ray diffraction, 1 ligand (WCS), 1 pocket (best druggability 0.46). MolNFT v1 #174109 on GenesisL1: 3D structure…
- PDB
- 7BLA
- Type
- protein
- Length
- 102 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Bromodomain adjacent to zinc finger domain protein 2A
- UniProt
- Q9UIF9
- Ligands
- WCS
- Pockets
- 1 · best druggability 0.46
Structure
x-ray diffraction · 1 distinct chain · 67% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Bromodomain adjacent to zinc finger domain protein 2A | protein | 102 | 67% helix, 0% strand | Q9UIF9 |
Ligands and binding sites
- WCS · 6-{4-[3-(dimethylamino)propoxy]phenyl}-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl) propyl]pyrimidin-4-amine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 86 | 0.46 | 0.80 | 20 | WCS |
Compared structures
- 7BLA · BAZ2A bromodomain in complex with TP-238 chemical probe · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UIF9 · AlphaFold monomer V2.0 prediction for bromodomain adjacent to zinc finger domain protein… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UIF9
- Elsewhere: RCSB PDB 7BLA · PDBe 7BLA · UniProt Q9UIF9
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