UniProt Q9UIF9
Bromodomain adjacent to zinc finger domain protein 2A (Q9UIF9)
Bromodomain adjacent to zinc finger domain protein 2A (UniProt Q9UIF9): 95 experimental structures and 1 predicted model on GenesisL1, 52 ligands bound, 57 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q9UIF9
- Protein
- Bromodomain adjacent to zinc finger domain protein 2A
- Experimental structures
- 95
- Predicted models
- 1
- Ligands
- 52
- Pockets
- 57 · 8 records with a druggable one
Structures
96 records of Q9UIF9 in the MolNFT archive: 95 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 4LZ2 | Crystal structure of the bromodomain of human BAZ2A | x-ray diffraction | A | — | — |
| 4LZ2 | Crystal structure of the bromodomain of human BAZ2A | x-ray diffraction | A | — | — |
| 4Q6F | Crystal structure of human BAZ2A PHD zinc finger in complex with unmodified H3K4 histone peptide | x-ray diffraction | A, B, C, D | — | — |
| 4Q6F | Crystal structure of human BAZ2A phd zinc finger in complex with unmodified H3K4 histone peptide | x-ray diffraction | A, B, C, D | — | — |
| 4QBM | Crystal structure of human BAZ2A bromodomain in complex with a diacetylated histone 4 peptide… | x-ray diffraction | A, B | — | — |
| 4QBM | Crystal structure of human BAZ2A bromodomain in complex with a diacetylated histone 4 peptide… | x-ray diffraction | A, B | — | — |
| 4QF2 | Crystal structure of human BAZ2A PHD zinc finger in the free form | x-ray diffraction | A, B, C, D | — | — |
| 4QF2 | Crystal structure of human BAZ2A phd zinc finger in the free form | x-ray diffraction | A, B, C, D | — | — |
| 5AGQ | Solution structure of the TAM domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA… | solution nmr | A | — | 1 (best 0.34) |
| 5AGQ | Solution structure of the tam domain of human TIP5 BAZ2A involved in epigenetic regulation of rRNA… | solution nmr | A | — | — |
| 5MGJ | Crystal Structure of BAZ2A bromodomain in complex with 1-methylpyridine derivative 1 | x-ray diffraction | A | 7MX | — |
| 5MGJ | Crystal structure of BAZ2A bromodomain in complex with 1- methylpyridine derivative 1 | x-ray diffraction | A | 7MX | — |
| 5MGK | Crystal Structure of BAZ2A bromodomain in complex with 4-propionyl-pyrrole derivative 2 | x-ray diffraction | A | 7MW | 1 (best 0.47) |
| 5MGK | Crystal structure of BAZ2A bromodomain in complex with 4-propionyl- pyrrole derivative 2 | x-ray diffraction | A | 7MW | — |
| 5MGL | Crystal Structure of BAZ2A bromodomain in complex with 4-chloropyridine derivative 3 | x-ray diffraction | A | 7MU | — |
| 5MGL | Crystal structure of BAZ2A bromodomain in complex with 4- chloropyridine derivative 3 | x-ray diffraction | A | 7MU | — |
| 5MGM | Crystal Structure of BAZ2A bromodomain in complex with acetophe derivative 4 | x-ray diffraction | A | 7MZ | — |
| 5MGM | Crystal structure of BAZ2A bromodomain in complex with acetophenone derivative 4 | x-ray diffraction | A | 7MZ | — |
| 5OR8 | Crystal Structure of BAZ2A bromodomain in complex with 1,3-dimethyl-benzimidazolone compound 1 | x-ray diffraction | A | JR4 | 1 (best 0.44) |
| 5OR8 | Crystal structure of BAZ2A bromodomain in complex with 1,3-dimethyl- benzimidazolone compound 1 | x-ray diffraction | A | JR4 | — |
| 5T8R | Crystal structure of human BAZ2A PHD zinc finger in complex with unmodified H3 10-mer | x-ray diffraction | A, B, C, D | ZN, PO4 | 3 (best 0.58) |
| 5T8R | Crystal structure of human BAZ2A phd zinc finger in complex with unmodified H3 10-mer | — | — | — | |
| 6FAP | Crystal structure of human BAZ2A PHD zinc finger in complex with Fr23 | x-ray diffraction | A, B, C, D | ZN, PO4, D3H | — |
| 6FAP | Crystal structure of human BAZ2A phd zinc finger in complex with FR23 | x-ray diffraction | A, B, C, D | ZN, PO4, D3H | — |
| 6FG6 | Crystal structure of BAZ2A bromodomain in complex with 1- methylpyridinone compound 1 | x-ray diffraction | A | D8Q | — |
| 6FGF | Crystal Structure of BAZ2A bromodomain in complex with 1-methylpyridi compound 2 | x-ray diffraction | A | EN2 | 1 (best 0.43) |
| 6FGF | Crystal structure of BAZ2A bromodomain in complex with 1- methylpyridinone compound 2 | x-ray diffraction | A | EN2 | — |
| 6FGG | Crystal Structure of BAZ2A bromodomain in complex with 1-methylpyridi compound 5 | x-ray diffraction | A | D9B | 1 (best 0.44) |
| 6FGG | Crystal structure of BAZ2A bromodomain in complex with 1- methylpyridinone compound 5 | x-ray diffraction | A | D9B | — |
| 6FGH | Crystal Structure of BAZ2A bromodomain in complex with 3-amino-2-methylpyridine derivative 1 | x-ray diffraction | A | 6RZ | 1 (best 0.43) |
| 6FGH | Crystal structure of BAZ2A bromodomain in complex with 3-amino-2- methylpyridine derivative 1 | x-ray diffraction | A | 6RZ | — |
| 6FGI | Crystal Structure of BAZ2A bromodomain in complex with 3-amino-2-methylpyridine derivative 2 | x-ray diffraction | A | D9K | 1 (best 0.44) |
| 6FGI | Crystal structure of BAZ2A bromodomain in complex with 3-amino-2- methylpyridine derivative 2 | x-ray diffraction | A | D9K | — |
| 6FGL | Crystal Structure of BAZ2A bromodomain in complex with acetylindole compound UZH47 | x-ray diffraction | A | UO1, MG | 1 (best 0.40) |
| 6FGL | Crystal structure of BAZ2A bromodomain in complex with acetylindole compound UZH47 | x-ray diffraction | A | UO1 | — |
| 6FGV | Crystal Structure of BAZ2A bromodomain in complex with 1-methylpyridi compound 3 | x-ray diffraction | A | D9T | 1 (best 0.47) |
| 6FGV | Crystal structure of BAZ2A bromodomain in complex with 1- methylpyridinone compound 3 | x-ray diffraction | A | D9T | — |
| 6FGW | Crystal Structure of BAZ2A bromodomain in complex with 1-methylpyridi compound 4 | x-ray diffraction | A | D9Q | 1 (best 0.42) |
| 6FGW | Crystal structure of BAZ2A bromodomain in complex with 1- methylpyridinone compound 4 | x-ray diffraction | A | D9Q | — |
| 6FHU | Crystal structure of BAZ2A PHD zinc finger in complex with H3 3-mer peptide | x-ray diffraction | A, B, C, D | ZN, PO4 | 4 (best 0.60) |
| 6FHU | Crystal structure of BAZ2A phd zinc finger in complex with H3 3-mer peptide | x-ray diffraction | A, B, C, D | ZN, PO4 | — |
| 6FI0 | Crystal structure of BAZ2A PHD zinc finger in complex with Fr 19 | x-ray diffraction | A, B, C, D | ZN, PO4, K, DEW | 2 (best 0.51) |
| 6FI0 | Crystal structure of BAZ2A phd zinc finger in complex with fr 19 | x-ray diffraction | A, B, C, D | ZN, PO4, K, DEW | — |
| 6FKP | Crystal structure of BAZ2A PHD zinc finger in complex with H3 10-mer AA mutant peptide | x-ray diffraction | A, B, C, D | ZN, PO4 | 3 (best 0.57) |
| 6FKP | Crystal structure of BAZ2A phd zinc finger in complex with H3 10-mer aa mutant peptide | x-ray diffraction | A, B, C, D | ZN, PO4 | — |
| 7B7B | BAZ2A bromodomain in complex with triazole compound MS04 | x-ray diffraction | A | T1B | 1 (best 0.45) |
| 7B7B | BAZ2A bromodomain in complex with triazole compound MS04 | x-ray diffraction | A | T1B | — |
| 7B7G | BAZ2A bromodomain in complex with compounds MS04 and B11 | x-ray diffraction | A | T1B, T1E | 1 (best 0.47) |
| 7B7G | BAZ2A bromodomain in complex with compounds MS04 and B11 | x-ray diffraction | A | T1B, T1E | — |
| 7B7I | BAZ2A bromodomain in complex with triazole compound MS04-TN02 | x-ray diffraction | A | T1H | 1 (best 0.45) |
| 7B7I | BAZ2A bromodomain in complex with triazole compound MS04-TN02 | x-ray diffraction | A | T1H | — |
| 7B82 | BAZ2A bromodomain in complex with triazole compound MS04-TN03 | x-ray diffraction | A | T3H | — |
| 7BC2 | BAZ2A bromodomain in complex with triazole compound MS04-TN04 | x-ray diffraction | A | T8Z | 1 (best 0.42) |
| 7BC2 | BAZ2A bromodomain in complex with triazole compound MS04-TN04 | x-ray diffraction | A | T8Z | — |
| 7BL8 | BAZ2A bromodomain in complex with the chemical probe BAZ2-ICR | x-ray diffraction | A | U1Z | 1 (best 0.44) |
| 7BL8 | BAZ2A bromodomain in complex with the chemical probe BAZ2-icr | x-ray diffraction | A | U1Z | — |
| 7BL9 | BAZ2A bromodomain in complex with GSK2801 chemical probe | x-ray diffraction | A | 3WQ | 1 (best 0.46) |
| 7BL9 | BAZ2A bromodomain in complex with GSK2801 chemical probe | x-ray diffraction | A | 3WQ | — |
| 7BLA | BAZ2A bromodomain in complex with TP-238 chemical probe | x-ray diffraction | A | WCS | 1 (best 0.46) |
| 7BLA | BAZ2A bromodomain in complex with tp-238 chemical probe | x-ray diffraction | A | WCS | — |
36 records more on the page itself.
Ligands
- MG · Magnesium ion · in 9 records
- PO4 · Phosphate ion · in 9 records
- ZN · Zinc ion · in 9 records
- UNX · Unknown atom or ion · in 6 records
- T1B · 5-ethyl-2-(3-methyl-1,2,3-triazol-4-yl)-1~{H}-benzimidazole · in 4 records
- 3WQ · 1-{1-[2-(methylsulfonyl)phenyl]-7-propoxyindolizin-3-yl}ethanone · in 2 records
- 6RZ · 2-methyl-~{N}-[(2~{R})-1-methylsulfonylpropan-2-yl]pyridin-3-amine · in 2 records
- 7MU · 4-chloranyl-~{N}-methyl-pyridine-2-carboxamide · in 2 records
- 7MW · methyl 4-propanoyl-1~{H}-pyrrole-2-carboxylate · in 2 records
- 7MX · ethyl 4-chloranyl-1-methyl-6-oxidanylidene-pyridine-3-carboxylate · in 2 records
- 7MZ · 1-(3-pyrimidin-2-yloxyphenyl)ethanone · in 2 records
- 9ST · 4-bromo-2-methyl-5-[[(3~{R},5~{R})-1-methyl-5-phenyl-piperidin-3-yl]amino]pyridazin-3-one · in 2 records
- D3H · ~{N}-(4-aminophenyl)-2-azanyl-ethanamide · in 2 records
- D9B · ~{N}-[3-[2-(dimethylamino)ethyl]-2-oxidanylidene-1,3-benzoxazol-5-yl]-1-methyl-6-oxidanylidene-pyridine-3-carboxamide · in 2 records
- D9K · ~{N}-[(3~{S})-1,1-bis(oxidanylidene)thian-3-yl]-2-methyl-pyridin-3-amine · in 2 records
- D9Q · 1-methyl-6-oxidanylidene-~{N}-(2-pyrrolidin-1-ylethyl) pyridine-3-carboxamide · in 2 records
- D9T · ~{N}-[(1-azanylcyclohexyl)methyl]-1-methyl-6-oxidanylidene-pyridine-3-carboxamide · in 2 records
- DEW · 2-azanyl-1-(6,7-dihydro-4~{H}-thieno[3,2-c]pyridin-5-yl)ethanone · in 2 records
- EN2 · ~{N}-[3-[(4-fluorophenyl)carbonylamino]propyl]-1-methyl-6-oxidanylidene-pyridine-3-carboxamide · in 2 records
- JR4 · ~{N}-[(4-fluorophenyl)methyl]-1,3,6-trimethyl-2-oxidanylidene-benzimidazole-5-sulfonamide · in 2 records
- K · Potassium ion · in 2 records
- T1E · 1-[1-(3,5-dimethoxyphenyl)piperidin-4-yl]-2,3-dimethyl-guanidine · in 2 records
- T1H · 2-[4-[[(~{E})-~{N},~{N}'-dimethylcarbamimidoyl]amino]piperidin-1-yl]-~{N}-[[2-(3-methyl-1,2,3-triazol-4-yl)-1~{H}-benzimidazol-5-yl]methyl]ethanamide · in 2 records
- T8Z · 2-(1-methyl-1H-1,2,3-triazol-5-yl)-5-((2-(pyridin-4-yl)pyrrolidin-1-yl)methyl)-1H-benzo[d]imidazole · in 2 records
- U1Z · 4-[5-(1-methylpyrazol-4-yl)-3-[2-(1-methylpyrazol-4-yl)ethyl]imidazol-4-yl]benzenecarbonitrile · in 2 records
- U2E · methyl 5-[(5-ethanoyl-2-ethoxy-phenyl)carbamoyl]-2-(2-piperazin-1-ylethoxy)benzoate · in 2 records
- U2K · 1-[3-(6-Methyl-2,3-dihydropyrazolo[5,1-b][1,3]oxazol-7-yl)indol-1-yl]ethanone · in 2 records
- UO1 · N-(1-acetyl-1H-indol-3-yl)-N-(5-hydroxy-2-methylphenyl)acetamide · in 2 records
- WCS · 6-{4-[3-(dimethylamino)propoxy]phenyl}-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl) propyl]pyrimidin-4-amine · in 2 records
- D8Q · ~{N}-(2-azanylethyl)-1-methyl-6-oxidanylidene-pyridine-3-carboxamide · in 1 record
Experiment against prediction
- 6FGG chain A against the predicted model Q9UIF9: TM-score 0.98, RMSD 0.47 Å
- 6FGG chain A against the predicted model Q9UIF9: TM-score 0.98, RMSD 0.47 Å
- 7QZ4 chain A against the predicted model Q9UIF9: TM-score 0.98, RMSD 0.50 Å
- 7R01 chain A against the predicted model Q9UIF9: TM-score 0.98, RMSD 0.50 Å
- 6FGV chain A against the predicted model Q9UIF9: TM-score 0.98, RMSD 0.51 Å
- 6FGV chain A against the predicted model Q9UIF9: TM-score 0.98, RMSD 0.51 Å
- 5MGL chain A against the predicted model Q9UIF9: TM-score 0.98, RMSD 0.51 Å
- 5MGL chain A against the predicted model Q9UIF9: TM-score 0.98, RMSD 0.51 Å
- 6FGI chain A against the predicted model Q9UIF9: TM-score 0.98, RMSD 0.52 Å
- 6FGI chain A against the predicted model Q9UIF9: TM-score 0.98, RMSD 0.52 Å
Elsewhere
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