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BAZ2A bromodomain in complex with tp-238 chemical probe

Analyse BAZ2A bromodomain in complex with tp-238 chemical probe in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 7BLA
Type: protein
Length: 102 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Bromodomain adjacent to zinc finger domain protein 2A
UniProt: Q9UIF9
Ligands: WCS
Pockets: 1 · best druggability 0.46

Structure

x-ray diffraction · 1 distinct chain · 67% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Bromodomain adjacent to zinc finger domain protein 2A	protein	102	67% helix, 0% strand	Q9UIF9

Ligands and binding sites

WCS · 6-{4-[3-(dimethylamino)propoxy]phenyl}-2-(methylsulfonyl)-N-[3-(1H-pyrazol-1-yl) propyl]pyrimidin-4-amine · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	86	0.46	0.80	20	WCS

Compared structures

7BLA · BAZ2A bromodomain in complex with TP-238 chemical probe · the same entry in another collection · chain A against A, TM-score 1.00
Q9UIF9 · AlphaFold monomer V2.0 prediction for bromodomain adjacent to zinc finger domain protein… · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9UIF9
Elsewhere: RCSB PDB 7BLA · PDBe 7BLA · UniProt Q9UIF9

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